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Value of Plasma Level of Endothelin-1 and Nitric Oxide in Diabetic Nephropathy

机译：血浆内皮素1和一氧化氮在糖尿病肾病中的价值。

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Endothelial dysfunction is the central pathophysiologic denominator for all microvascular complications of diabetes, including nephropathy. Abnormalities of endothelin-1 and nitric oxide (NO) modulate renal structure and function in diabetes. We study the role of endothelin-1 and NO in the diabetic kidney. This study includes a total of 60 type-2 diabetic patients and 20 healthy subjects as a control group (group 1). Diabetics were classified into three groups. Group 2 included 20 patients without microalbuminuria, group 3 included 20 patients with microalbuminuria, and group 4 included 20 patients with macroalbuminuria. All individuals were subjected to history taking, physical examination, urine analysis, HbA1C test, kidney function tests, abdominal ultrasonography, and evaluation of urinary albumin concentration, nitric oxide levels, and plasma endothelin-1 (ET-1) levels. Our results showed an elevated plasma level of endothelin-1 of 4.09 ± 0.32, 5.04 ± 0.20, and 5.74 ± 0.11 pg/ml for group 2, 3, and 4, respectively, an elevated plasma level of nitric oxide in type-2 diabetic patients with early stages of diabetic nephropathy, and a decreased level in late stages of diabetic nephropathy of 40.08 ± 1.66, 46.11 ± 1.75, and 31.17 ± 2.16 μmol/l for group 2, 3, and 4, respectively. There was a statistically significant difference between all groups and the control group regarding NO and ET-1 (p < 0.001 and p < 0.001, respectively). The enhanced NO production may contribute to hyperfiltration in early diabetic nephropathy. ET-1 may have a role in microvascular damage in diabetics. Targeting the ET-1 system might be potentially beneficial in preventing and/or treating kidney disease in diabetics.
机译：内皮功能障碍是糖尿病所有微血管并发症（包括肾病）的主要病理生理指标。内皮素-1和一氧化氮（NO）异常调节糖尿病患者的肾脏结构和功能。我们研究了内皮素-1和一氧化氮在糖尿病肾中的作用。这项研究包括60名2型糖尿病患者和20名健康受试者作为对照组（第1组）。糖尿病患者分为三组。第2组包括20例无微量白蛋白尿的患者，第3组包括20例有微量白蛋白尿的患者，第4组包括20例有微量白蛋白尿的患者。所有患者均接受历史记录，体格检查，尿液分析，HbA1C测试，肾脏功能测试，腹部超声检查，并评估尿白蛋白浓度，一氧化氮水平和血浆内皮素-1（ET-1）水平。我们的结果显示，第2组，第3组和第4组血浆内皮素1的血浆水平分别升高4.09±0.32、5.04±0.20和5.74±0.11 pg / ml，而2型糖尿病患者的一氧化氮血浆水平升高。第2组，第3组和第4组的糖尿病肾病早期患者以及糖尿病肾病晚期患者的降低水平分别为40.08±1.66、46.11±1.75和31.17±2.16μmol/ l。在所有组和对照组之间，NO和ET-1差异均有统计学意义（分别为p <0.001和p <0.001）。 NO产生的增加可能有助于早期糖尿病肾病的超滤。 ET-1可能在糖尿病患者的微血管损伤中起作用。靶向ET-1系统可能在预防和/或治疗糖尿病患者的肾脏疾病方面可能具有潜在优势。

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