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首页> 外文期刊>Lipids >Soy-Based Infant Formula Supplemented with DHA and ARA Supports Growth and Increases Circulating Levels of these Fatty Acids in Infants
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Soy-Based Infant Formula Supplemented with DHA and ARA Supports Growth and Increases Circulating Levels of these Fatty Acids in Infants

机译：补充DHA和ARA的大豆基婴儿配方食品可促进婴儿体内这些脂肪酸的生长并提高其循环水平

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Healthy term infants (n = 244) were randomized to receive: (1) control, soy-based formula without supplementation or (2) docosahexaenoic acid−arachidonic acid (DHA + ARA), soy-based formula supplemented with at least 17 mg DHA/100 kcal (from algal oil) and 34 mg ARA/100 kcal (from fungal oil) in a double-blind, parallel group trial to evaluate safety, benefits, and growth from 14 to 120 days of age. Anthropometric measurements were taken at 14, 30, 60, 90, and 120 days of age and 24-h dietary and tolerance recall were recorded at 30, 60, 90, and 120 days of age. Adverse events were recorded throughout the study. Blood samples were drawn from subsets of 25 infants in each group. Capillary column gas chromatography was used to analyze the percentages of fatty acids in red blood cell (RBC) lipids and plasma phospholipids. Compared with the control group, percentages of fatty acids such as DHA and ARA in total RBC and plasma phospholipids were significantly higher in infants in the DHA + ARA group at 120 days of age (P < 0.001). Growth rates did not differ significantly between feeding groups at any assessed time point. Supplementation did not affect the tolerance of formula or the incidence of adverse events. Feeding healthy term infants soy-based formula supplemented with DHA and ARA from single cell oil sources at concentrations similar to human milk significantly increased circulating levels of DHA and ARA when compared with the control group. Both formulas supported normal growth and were well tolerated.
机译：健康足月婴儿（n = 244）被随机分配接受：（1）对照，不添加大豆的配方奶粉或（2）二十二碳六烯酸-花生四烯酸（DHA + ARA），补充了至少17 mg DHA的大豆配方奶粉在一项双盲平行小组试验中，评估了100 kcal（来自藻油）和34 mg ARA / 100 kcal（来自真菌油），以评估14天至120天龄的安全性，益处和生长。在14、30、60、90和120天龄时进行人体测量，并在30、60、90和120天龄时记录24小时饮食和耐受性。在整个研究中记录不良事件。从每组25名婴儿的子集中抽取血样。毛细管柱气相色谱法用于分析红细胞（RBC）脂质和血浆磷脂中脂肪酸的百分比。与对照组相比，DHA + ARA组120天婴儿的总红细胞和血浆磷脂中脂肪酸（如DHA和ARA）的百分比显着更高（P <0.001）。在任何评估的时间点，喂养组之间的增长率没有显着差异。补充剂不影响配方的耐受性或不良事件的发生率。与对照组相比，从单细胞油源中补充了DHA和ARA的健康足月婴儿大豆基配方食品喂养的浓度与人乳相似，显着提高了DHA和ARA的循环水平。两种配方均支持正常生长且耐受性良好。

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