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首页> 外文期刊>Materials Science and Engineering >In vitro secretion of TNF-α from bone marrow mononuclear cells incubated on amino group modified TiO_2 nano-composite under ultrasound irradiation
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In vitro secretion of TNF-α from bone marrow mononuclear cells incubated on amino group modified TiO_2 nano-composite under ultrasound irradiation

机译：氨基修饰的TiO_2纳米复合材料在超声照射下培养的骨髓单个核细胞中TNF-α的体外分泌

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摘要

It is recently known that titanium dioxide (TiO_2) can be excited by ultrasound and release of OH radicals on the surface. In this study, secretion of an indirect angiogenic factor, tumor necrosis factor-α (TNF-α), from bone marrow mononuclear cells (BM-MNC) incubated on amino group modified TiO_2 nano-particles covalently coated on polyester fabric (TiO_2/PET) under ultrasonic irradiation was examined in vitro. The cell viability and TNF-a secretion were measured under ultrasound irradiation condition with 255mW/cm~2 of intensity, which is below the highest output (1 W/cm~2) specified in the safety standard for a medical ultrasonic diagnostic apparatus.The living cell number on the TiO_2/PETand original PET with/without continuous ultrasound irradiation was unchanged statistically by ANOVA test. TNF-α secretion level from BM-MNC remarkably increased on the TiO_2/PET under ultrasonic irradiation without cell damage. It was, therefore, thought that the high level of TNF-a secretion on the TiO_2 nano-composite by ultrasound irradiation was due to oxidative stress induced from OH radicals on TiO_2.
机译：最近已知，二氧化钛（TiO 2）可以通过超声波被激发并在表面上释放OH基。在这项研究中，在共价包覆在聚酯织物（TiO_2 / PET）上的氨基修饰的TiO_2纳米颗粒上孵育的骨髓单核细胞（BM-MNC）中分泌一种间接的血管生成因子，肿瘤坏死因子-α（TNF-α）。 ）在超声辐射下进行体外检查。在超声辐照条件下以255mW / cm〜2的强度测量细胞活力和TNF-a分泌，该强度低于医疗超声诊断设备安全标准中规定的最高输出（1 W / cm〜2）。通过ANOVA测试，在有/无连续超声照射下，TiO_2 / PET和原始PET上的活细胞数在统计学上没有变化。在超声照射下，TiO_2 / PET在无细胞损伤的情况下，BM-MNC的TNF-α分泌水平显着增加。因此，认为通过超声辐射在TiO_2纳米复合材料上高水平的TNF-α分泌是由于由TiO_2上的OH自由基引起的氧化应激。

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  • 来源
    《Materials Science and Engineering》 |2010年第3期|P.191-194|共4页
  • 作者

    T. Furuzono; M. Masuda; N. Nitta; A. Kaya; T. Yamane; M. Okada;

  • 作者单位

    Department of Bioengineering, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, 5-7-I Fujishiro-dai, Suita, Osaka 565-8565, Japan;

    rnDepartment of Bioengineering, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, 5-7-I Fujishiro-dai, Suita, Osaka 565-8565, Japan;

    Institute for Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology, 1-2-1 Namiki, Tsukuba, Ibaraki, 305-8564, Japan;

    rnInstitute for Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology, 1-2-1 Namiki, Tsukuba, Ibaraki, 305-8564, Japan;

    rnInstitute for Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology, 1-2-1 Namiki, Tsukuba, Ibaraki, 305-8564, Japan;

    rnDepartment of Bioengineering, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, 5-7-I Fujishiro-dai, Suita, Osaka 565-8565, Japan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    titanium dioxide; composite; ultrasound; angiogenic factor;

    机译：二氧化钛;综合;超声波血管生成因子;

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