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首页> 外文期刊>Materials science & engineering >The influence of selected ω-mercaptocarboxylate ligands on physicochemical properties and biological activity of Cd-free, zinc-copper-indium sulfide colloidal nanocrystals
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The influence of selected ω-mercaptocarboxylate ligands on physicochemical properties and biological activity of Cd-free, zinc-copper-indium sulfide colloidal nanocrystals

机译：选定的ω-巯基羧酸盐配体对无镉，锌-铜-铟-铟硫化物胶体纳米晶体的理化性质和生物活性的影响

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摘要

In this work core/shell cadmium-free zinc-copper-indium sulfide ZnCuInS/ZnS quantum dots (QDs) originally stabilized with hydrophilic alkanethiol were modified with 3-mercaptopropionic acid (MPA) or 6-mercaptohexanoic acid (MHA) via two-step ligand exchange method. The obtained QDs were further characterized by TEM, UV Vis, and fluorescence spectroscopy. Both types of QDs were non-toxic in a wide range of concentrations. To our knowledge, our studies are the first attempt to determine the type of cell death and reactive oxygen species production level as a result of incubation of cell cultures with ZnCuInS/ZnS QDs. Furthermore, the accumulation of QDs in vitro was examined on three human cell lines by fluorescence intensity measurements and visualized by confocal microscopy. The modification of QDs with a ligand characterized by slightly longer aliphatic chain (MHA), instead of typically used MPA turns out to be beneficial both from the point of colloidal stability, preservation of optical properties during ligand exchange as well as reflects in a higher cellular uptake. This contribution can be beneficial from the point of view of the selection of the optimal ligands and concentrations in the case of ZnCuInS/ZnS core-shell QDs for biological applications.
机译：在这项工作中，最初用亲水性链烷硫醇稳定的核/壳无镉锌铜-铟-铟ZnCuInS / ZnS量子点（QD）通过两步3-巯基丙酸（MPA）或6-巯基己酸（MHA）改性配体交换方法。通过TEM，UV Vis和荧光光谱进一步表征获得的QD。两种类型的量子点在很宽的浓度范围内都是无毒的。据我们所知，我们的研究是确定细胞培养物与ZnCuInS / ZnS QDs孵育后细胞死亡类型和活性氧产生水平的首次尝试。此外，通过荧光强度测量在三种人细胞系上检查了体外量子点的积累，并通过共聚焦显微镜对其进行了可视化。从胶体稳定性，在配体交换过程中保留光学特性以及在更高的细胞中反映出来的角度来看，用特征在于稍长的脂肪族链（MHA）而不是通常使用的MPA的配体修饰QD都是有益的吸收。从为生物应用选择ZnCuInS / ZnS核壳QD的最佳配体和浓度的角度来看，这一贡献可能是有益的。

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