...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Materials science & engineering >Reducing Escherichia coli growth on a composite biomaterial by a surface immobilized antimicrobial peptide
【24h】

Reducing Escherichia coli growth on a composite biomaterial by a surface immobilized antimicrobial peptide

机译：通过表面固定的抗菌肽减少大肠杆菌在复合生物材料上的生长

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A new composite bioceramic consisting of calcium aluminum oxide (CaAlO) and hydroxyapatite (HA) was func-tionalized with the synthetic antimicrobial peptide Inverso-CysHHC10. CaAlO is a bioceramic that can be mold cast easily and quickly at room temperature. Improved functionality was previously achieved through surface reactions. Here, composites containing 0-5% HA (by mass) were prepared and the elastic modulus and modulus of rupture were mechanically similar to non-load bearing bone. The addition of hydroxyapatite resulted in increased osteoblast attachment (＞180%) and proliferation (＞140%) on all composites compared to 100% CaAlO. Antimicrobial peptide (AMP) immobilization was achieved using an interfacial alkene-thiol click reaction. The linked AMP persisted on the composite (＞99.6% after 24 h) and retained its activity against Escherichia coli based on N-phenylnaphthylamine uptake and bacterial turbidity tests. Overall, this simple scaffold system improves osteoblast activity and reduces bacterial activity.
机译：用合成的抗菌肽Inverso-CysHHC10功能化了一种由铝酸钙（CaAlO）和羟基磷灰石（HA）组成的新型复合生物陶瓷。 CaAlO是一种生物陶瓷，可以在室温下轻松快速地铸模。先前通过表面反应实现了改进的功能。在这里，制备了包含0-5％HA（按质量计）的复合材料，其弹性模量和断裂模量在机械上类似于非承重骨。与100％CaAlO相比，添加羟基磷灰石可使所有复合材料的成骨细胞附着增加（> 180％）和增殖（> 140％）。抗菌肽（AMP）的固定是通过使用界面烯烃-巯基点击反应实现的。连接的AMP在复合材料上持续存在（24小时后＞ 99.6％），并根据N-苯基萘胺的摄取和细菌浊度测试，保留了其对大肠杆菌的活性。总体而言，这种简单的支架系统可改善成骨细胞活性并降低细菌活性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号