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首页> 外文期刊>Materials science & engineering >Preparation of TiO_2 nanotubes/mesoporous calcium silicate composites with controllable drug release
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Preparation of TiO_2 nanotubes/mesoporous calcium silicate composites with controllable drug release

机译：可控药物释放的TiO_2纳米管/介孔硅酸钙复合材料的制备

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摘要

Nanotube structures such as TiO_2 nanotube (TNT) arrays produced by self-ordering electrochemical anodization have been extensively explored for drug delivery applications. In this study, we presented a new implantable drug delivery system that combined mesoporous calcium silicate coating with nanotube structures to achieve a controllable drug release of water soluble and antiphlogistic drug loxoprofen sodium. The results showed that the TiO_2 nanotubes/mesoporous calcium silicate composites were successfully fabricated by a simple template method and the deposition of mesoporous calcium silicate increased with the soaking time. Moreover, the rate of deposition of biological mesoporous calcium silicate on amorphous TNTs was better than that on an-atase TNTs. Further, zinc-incorporated mesoporous calcium silicate coating, produced by adding a certain concentration of zinc nitrate into the soaking system, displayed improved chemical stability. A significant improvement in the drug release characteristics with reduced burst release and sustained release was demonstrated.
机译：通过自序电化学阳极氧化生产的纳米管结构，例如TiO_2纳米管（TNT）阵列，已广泛用于药物输送应用。在这项研究中，我们提出了一种新的可植入药物输送系统，该系统将中孔硅酸钙涂层与纳米管结构结合在一起，从而实现了水溶性和消炎药洛索洛芬钠的可控药物释放。结果表明，采用简单的模板法成功制备了TiO_2纳米管/介孔硅酸钙复合材料，介孔硅酸钙的沉积量随浸泡时间的增加而增加。而且，生物中孔硅酸钙在无定形TNT上的沉积速率比在锐钛型TNT上的沉积速率要好。此外，通过在浸泡体系中加入一定浓度的硝酸锌制成的掺锌的介孔硅酸钙涂层，具有改善的化学稳定性。证明了药物释放特性的显着改善，其中突发释放和持续释放减少。

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  • 来源
    《Materials science & engineering》 |2016年第10期|433-439|共7页
  • 作者

    Chunling Xie; Ping Li; Yan Liu; Fei Luo; Xiufeng Xiao;

  • 作者单位

    College of Chemistry and Chemical Engineering, Fujian Normal University, Fuzhou, Fujian 350007, China;

    College of Chemistry and Chemical Engineering, Fujian Normal University, Fuzhou, Fujian 350007, China;

    College of Chemistry and Chemical Engineering, Fujian Normal University, Fuzhou, Fujian 350007, China;

    College of Chemistry and Chemical Engineering, Fujian Normal University, Fuzhou, Fujian 350007, China;

    College of Chemistry and Chemical Engineering, Fujian Normal University, Fuzhou, Fujian 350007, China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    TiO_2 nanotube; Mesoporous calcium silicate; Zinc; Loxoprofen sodium; Drug delivery;

    机译：TiO_2纳米管;介孔硅酸钙;锌;洛索洛芬钠;药物输送;

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