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首页> 外文期刊>Materials science & engineering, C. Materials for Biogical applications >Preparation of TiO2 nanotubes/mesoporous calcium silicate composites with controllable drug release
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Preparation of TiO2 nanotubes/mesoporous calcium silicate composites with controllable drug release

机译：可控药物释放的TiO2纳米管/介孔硅酸钙复合材料的制备

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摘要

Nanotube structures such as TiO2 nanotube (TNT) arrays produced by self-ordering electrochemical anodization have been extensively explored for drug delivery applications. In this study, we presented a new implantable drug delivery system that combined mesoporous calcium silicate coating with nanotube structures to achieve a controllable drug release of water soluble and antiphlogistic drug loxoprofen sodium. The results showed that the TiO2 nanotubes/mesoporous calcium silicate composites were successfully fabricated by a simple template method and the deposition of mesoporous calcium silicate increased with the soaking time. Moreover, the rate of deposition of biological mesoporous calcium silicate on amorphous TNTs was better than that on anatase TNTs. Further, zinc-incorporated mesoporous calcium silicate coating, produced by adding a certain concentration of zinc nitrate into the soaking system, displayed improved chemical stability. A significant improvement in the drug release characteristics with reduced burst release and sustained release was demonstrated. (C) 2016 Elsevier B.V. All rights reserved.
机译：通过自序电化学阳极氧化生产的纳米管结构（如TiO2纳米管（TNT）阵列）已广泛用于药物输送应用。在这项研究中，我们提出了一种新的可植入药物输送系统，该系统将中孔硅酸钙涂层与纳米管结构结合在一起，从而实现了水溶性和消炎药洛索洛芬钠的可控药物释放。结果表明，采用简单的模板法成功制备了TiO2纳米管/介孔硅酸钙复合材料，介孔硅酸钙的沉积量随浸泡时间的增加而增加。此外，生物中孔硅酸钙在无定形TNTs上的沉积速率要好于锐钛矿型TNTs。此外，通过在浸泡体系中添加一定浓度的硝酸锌而制得的掺锌的介孔硅酸钙涂层具有改善的化学稳定性。证明了药物释放特性的显着改善，其中突发释放和持续释放减少。 （C）2016 Elsevier B.V.保留所有权利。

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