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首页> 外文期刊>Materials science & engineering >Silver nanoparticles impregnated chitosan layered carbon nanotube as sensor interface for electrochemical detection of clopidogrel in-vitro
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Silver nanoparticles impregnated chitosan layered carbon nanotube as sensor interface for electrochemical detection of clopidogrel in-vitro

机译：银纳米粒子浸渍壳聚糖层状碳纳米管作为传感器界面，用于氯吡格雷的电化学检测

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摘要

Continuous periodical monitoring of clopidogrel in physiological body fluids is indispensable in medical diagnosis of heart ailments and cardiovascular diseases. A highly sensitive electrochemical sensor has been fabricated with silver nanoparticles embedded chitosan-carbon nanotube hybrid composite (AgChit-CNT) as sensor interface for detection of the important anti-platelet drug, clopidogrel (CLP). Synthesized AgChit-CNT nanocomposite is examined by x-ray diffraction, Raman spectroscopy and field emission scanning electron microscopy for its chemical and structural characteristics. Crystalline silver nanoparticles of about 35 nm are well distributed in the composite and have formed continuous chain like linkages with CNTs all throughout. Electrochemical responses of the fabricated AgChit-CNT nanocomposite electrode for the determination of CLP have been examined by cyclic voltammetry and electrochemical impedance spectroscopy. The nanoAg patterned CNT nanocomposite interface acts as an excellent electron transfer mediator towards the oxidation of clopidogrel. Electrochemical determination of CLP was investigated by differential pulse voltammetry (DPV) and amperometric analysis under optimized conditions. The limit of detection by DPV and amperometry were 30 nM and 10 nM, respectively, and the time of the analysis is as low as 10 s. Practical applicability for determination in artificially prepared urine and pharmaceutical formulation has been examined with good recovery limits of 95.2 to 102.6%.
机译：连续定期监测生理体液中的氯吡格雷是心脏病和心血管疾病的医学诊断中不可或缺的。具有高敏感的电化学传感器，用银纳米粒子嵌入壳聚糖 - 碳纳米管杂交复合材料（Agchit-CNT）作为传感器界面，用于检测重要的抗血小板药物，氯吡格雷（CLP）。通过X射线衍射，拉曼光谱和场发射扫描电子显微镜检查合成的Agchit-CNT纳米复合物，用于其化学和结构特征。结晶银纳米颗粒的约35nm在复合材料中分布良好，并形成连续链，如整个CNT的连续链。通过循环伏安法和电化学阻抗光谱检查制造的Agchit-CNT纳米复合材料的电化学响应，用于测定CLP。纳米图案化的CNT纳米复合界面用作优异的电子转移介质朝向氯吡格雷的氧化作用。通过差分脉冲伏安法（DPV）研究了CLP的电化学测定，并在优化条件下进行了电压分析。通过DPV和安培测量的检测极限分别为30nm和10nm，分析的时间低至10 s。在人工制备的尿液和药物制剂中测定的实际适用性已经检查了95.2％至102.6％的良好恢复限值。

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