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Stimulus-responsive hydrogels: Theory, modern advances, and applications

机译:刺激响应水凝胶:理论,现代进展和应用

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摘要

Over the past century, hydrogels have emerged as effective materials for an immense variety of applications. The unique network structure of hydrogels enables very high levels of hydrophilicity and biocompatibility, while at the same time exhibiting the soft physical properties associated with living tissue, making them ideal biomaterials. Stimulus-responsive hydrogels have been especially impactful, allowing for unprecedented levels of control over material properties in response to external cues. This enhanced control has enabled groundbreaking advances in healthcare, allowing for more effective treatment of a vast array of diseases and improved approaches for tissue engineering and wound healing. In this extensive review, we identify and discuss the multitude of response modalities that have been developed, including temperature, pH, chemical, light, electro, and shear-sensitive hydrogels. We discuss the theoretical analysis of hydrogel properties and the mechanisms used to create these responses, highlighting both the pioneering and most recent work in all of these fields. Finally, we review the many current and proposed applications of these hydrogels in medicine and industry.
机译:在过去的一个世纪中,水凝胶已成为各种应用中的有效材料。水凝胶的独特网络结构可实现非常高的亲水性和生物相容性,同时具有与活组织相关的柔软物理特性,使其成为理想的生物材料。刺激响应水凝胶尤其具有影响力,可以根据外部提示对材料特性进行前所未有的控制。这种增强的控制使医疗保健取得了突破性的进展,可以更有效地治疗多种疾病,并改善了组织工程和伤口愈合的方法。在这篇广泛的综述中,我们确定并讨论了已开发的多种响应方式,包括温度,pH,化学,光,电和剪切敏感性水凝胶。我们讨论了水凝胶性质的理论分析以及用于产生这些反应的机理,重点介绍了所有这些领域的开拓性和最新工作。最后,我们回顾了这些水凝胶在医学和工业中的许多当前和提议的应用。

著录项

  • 来源
    《Materials Science & Engineering》 |2015年第7期|1-49|共49页
  • 作者单位

    McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, United States,Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX 78712, United States;

    McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, United States,Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX 78712, United States;

    Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, United States,Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX 78712, United States;

    McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, United States,Department of Biomedical Engineering, The University of Texas at Austin, 107W Dean Keeton Street, Stop C0800, Austin, TX 78712, United States,College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, United States,Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX 78712, United States;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Hydrogels; Polymers; Stimulus-responsive; Smart materials; Swelling; Drug delivery; pH responsive; Temperature responsive; Chemically-responsive; Molecularly imprinted polymers; Photo-responsive; Electrically-responsive; Shear stress; Scaffolds; Tissue engineering; Biosensors;

    机译:水凝胶;聚合物;刺激反应;智能材料;肿胀;药物输送;pH响应;温度响应;化学反应性分子印迹聚合物;光敏;电气响应;剪应力;脚手架组织工程;生物传感器;

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