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首页> 外文期刊>Mechatronics, IEEE/ASME Transactions on >Control of Single-Cell Migration Using a Robot-Aided Stimulus-Induced Manipulation System
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Control of Single-Cell Migration Using a Robot-Aided Stimulus-Induced Manipulation System

机译：使用机器人辅助的刺激诱导操纵系统控制单细胞迁移。

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摘要

Cell migration is a natural movement that occurs in response to stimuli in a living environment. Analysis and control of cell-migration behavior can help elucidate various developmental and maintenance processes of multicellular organisms, thereby contributing to the development of new target therapy approaches. In this study, we successfully achieved the automated control of single-cell migration by utilizing the intrinsic migration ability of cells in an engineering control framework. Chemoattractant-loaded microsource beads trapped by robotically controlled optical tweezers were used to release the stimuli and consequently induce target cells to migrate into a desired region. Cell-movement dynamics under optical tweezer manipulation was analyzed. A new geometric model that confined microsource beads within the effective trapping area of the optical tweezers and the high-motility area of the cell under study was established. Based on this model, we developed a potential field function-based controller that handled the optical tweezers in manipulating the microsource beads, thereby stimulating cells to migrate into desired regions. Simulations and experiments were further performed to verify the effectiveness of the proposed approach.
机译：细胞迁移是一种自然运动，响应于生活环境中的刺激而发生。细胞迁移行为的分析和控制可以帮助阐明多细胞生物的各种发育和维持过程，从而有助于开发新的靶标治疗方法。在这项研究中，我们通过在工程控制框架中利用细胞的固有迁移能力，成功实现了单细胞迁移的自动化控制。由机械手控制的光镊捕获的载有趋化剂的微源珠被用于释放刺激物，从而诱导靶细胞迁移到所需区域。分析了光镊操作下的细胞运动动力学。建立了一个新的几何模型，该模型将微源珠子限制在光镊的有效捕获区域和被研究细胞的高运动区域内。基于此模型，我们开发了一种基于潜在场函数的控制器，该控制器在操纵微源珠子时处理了光镊，从而刺激细胞迁移到所需区域。进一步进行仿真和实验以验证所提出方法的有效性。

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