Increased Number of MicroRNA Target Sites in Genes Encoded in CNV Regions. Evidence for an Evolutionary Genomic Interaction

Constantinos Deltas

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Increased Number of MicroRNA Target Sites in Genes Encoded in CNV Regions. Evidence for an Evolutionary Genomic Interaction

机译：CNV区域编码基因中MicroRNA靶位点的数量增加。进化基因组相互作用的证据

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MicroRNAs (miRNAs) and copy number variations (CNVs) are two newly discovered genetic elements that have revolutionized the field of molecular biology and genetics. By performing in silico whole genome analysis, we demonstrate that both the number of miRNAs that target genes found in CNV regions as well as the number of miRNA-binding sites are significantly higher than those of genes found in non-CNV regions. This suggests that miRNAs may have acted as equilibrators of gene expression during evolution in an attempt to regulate aberrant gene expression and to increase the tolerance to genome plasticity.

机译：MicroRNA（miRNA）和拷贝数变异（CNV）是两个新发现的遗传要素，彻底改变了分子生物学和遗传学领域。通过进行计算机模拟全基因组分析，我们证明了靶向CNV区域中发现的基因的miRNA数量以及miRNA结合位点的数量均显着高于非CNV区域中发现的基因。这表明，miRNA可能在进化过程中充当了基因表达的平衡者，试图调节异常的基因表达并提高对基因组可塑性的耐受性。

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《Molecular Biology and Evolution》 |2011年第9期|p.2421-2424|共4页
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1. Increased Number of MicroRNA Target Sites in Genes Encoded in CNV Regions. Evidence for an Evolutionary Genomic Interaction [J] . Felekkis Kyriakos, Voskarides Konstantinos, Dweep Harsh, Molecular biology and evolution . 2011,第9期

机译：CNV区域编码基因中MicroRNA靶位点的数量增加。进化基因组相互作用的证据
2. Evolutionary Changes of the Target Sites of Two MicroRNAs Encoded in the Hox Gene Cluster of Drosophila and Other Insect Species [J] . Masafumi Nozawa, Masatoshi Nei, Sayaka Miura Genome Biology and Evolution . 2011,第3期

机译：果蝇和其他昆虫物种Hox基因群中的两种microRNA靶位点的进化变化
3. Evolutionary Conservation of MicroRNA Regulatory Circuits: An Examination of MicroRNA Gene Complexity and Conserved MicroRNA-Target Interactions through Metazoan Phylogeny [J] . Chung-Tien Lee Tyler Risom William M. Strauss DNA and Cell Biology . 2007,第4期

机译：MicroRNA调节电路的进化保守性：通过后生系统发育检查MicroRNA基因的复杂性和保守的MicroRNA靶相互作用。
4. A semantic approach for knowledge capture of MIcroRNA-Target gene interactions [C] . Huang Jingshan, Gutierrez Fernando, Dou Dejing, IEEE International Conference on Bioinformatics and Biomedicine . 2015

机译：用于MIcroRNA-Target基因相互作用的知识捕获的语义方法
5. Evolutionary and biochemical genomic investigation of three gene families encoding enzymes of plant specialized metabolism. [D] . D'Auria, John Charles, II. 2002

机译：进化和生化基因组学研究的三个基因家族编码植物专门代谢酶。
6. Evolutionary Changes of the Target Sites of Two MicroRNAs Encoded in the Hox Gene Cluster of Drosophila and Other Insect Species [O] . Sayaka Miura, Masafumi Nozawa, Masatoshi Nei 2011

机译：果蝇和其他昆虫Hox基因簇中编码的两个MicroRNA的靶位的进化变化。
7. Increased Number of MicroRNA Target Sites in Genes Encoded in CNV Regions. Evidence for an Evolutionary Genomic Interaction [O] . Constantinos Deltas 2016

机译：CNV区域编码基因中微小RNa靶位点数量的增加。进化基因组相互作用的证据
8. DNA Sequences of Genes Encoding Acinetobacter calcoaceticus Protocatechuate 3,4-Dioxygenase: Evidence Indicating Shuffling of Genes and of DNA Sequences within Genes during Their Evolutionary Divergence [R] . Hartnett, C., Neidle, E. L., Ngai, K. L., 1990

机译：编码醋酸钙不动杆菌原儿茶酸3,4-二氧化酶基因的DNa序列：证据表明基因在进化发散过程中基因和DNa序列的改组

Increased Number of MicroRNA Target Sites in Genes Encoded in CNV Regions. Evidence for an Evolutionary Genomic Interaction

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