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Detection and qualification of optimum antibacterial and cytotoxic activities of silver-doped bioactive glasses

机译：掺银生物活性玻璃的最佳抗菌和细胞毒性活性的检测和鉴定

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摘要

This study aims to detect the optimum antibacterial activity of silver-doped bioactive glasses (Ag-BGs) for prevention of post-transplant infections in tissue engineering. The results have shown that the Ag-BG samples had broad-spectrum antibacterial efficacy in an Ag concentration-dependent manner. The 2% Ag-BG had the highest effect during the first 10 min to 72 h. The minimum inhibitory concentration of 2% Ag-BG was estimated to be 2 mg/ml for () and () and 2.66 mg/ml for (). A concentration of 0.5% Ag-BG repressed growth of after 1 h, but did not have any detectable antibacterial effect for longer periods. Evaluation of the effects of prepared Ag-BG on human osteoblast cells viability showed that 1 and 2% samples changed the cell proliferation rate in masses of more than 3.33 and 2 mg/ml, respectively. Moreover, in a typical manner, the release of Ag ions from the glass structure started immediately, continued steadily and affected bacterial growth when it reached its critical concentration in the medium. This systematic study can illustrate the optimum antibacterial property of the Ag-BG samples in masses of 3.33 and 2 mg/ml for 1 and 2% Ag, respectively, for prevention of post-transplant infections.
机译：这项研究旨在检测最佳的抗菌活性银掺杂玻璃（Ag-BGs），以防止组织工程中的移植后感染。结果表明，Ag-BG样品具有依赖于Ag浓度的方式的广谱抗菌功效。在最初的10分钟至72小时内，含2％Ag-BG的效果最高。 2％Ag-BG的最低抑菌浓度估计对于（）和（）为2 mg / ml，对于（）为2.66 mg / ml。 0.5％Ag-BG的浓度可抑制1小时后的生长，但在更长的时间内没有任何可检测的抗菌作用。评估制备的Ag-BG对人成骨细胞活力的影响后，发现1％和2％的样品分别以超过3.33和2 mg / ml的质量改变了细胞增殖率。而且，以典型的方式，当银离子在培养基中达到其临界浓度时，Ag离子立即开始从玻璃结构中释放出来，稳定持续并影响细菌生长。这项系统的研究可以说明，分别用于防止1％和2％Ag的Ag-BG样品的最佳抗菌性能分别为3.33和2 mg / ml，以防止移植后感染。

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