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首页> 外文期刊>Nanobiotechnology, IET >Biosynthesis of tellurium nanoparticles by Lactobacillus plantarum and the effect of nanoparticle-enriched probiotics on the lipid profiles of mice
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Biosynthesis of tellurium nanoparticles by Lactobacillus plantarum and the effect of nanoparticle-enriched probiotics on the lipid profiles of mice

机译：植物乳杆菌生物合成碲纳米粒子以及富含纳米粒子的益生菌对小鼠脂质分布的影响

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摘要

Hypercholesterolemia is an important risk factor contributing to atherosclerosis and coronary heart disease. Lactic acid bacteria have attracted much attention regarding their promising effect on serum cholesterol levels. Tellurium (Te) is a rare element that has also gained considerable interest for its biological effects. There have been some recent reports on the reduction effect of Te on cholesterol content. In this study, PTCC 1058 was employed for the intracellular biosynthesis of Te NPs. The UV-visible spectrum of purified NPs showed a peak at 214 nm related to the surface plasmon resonance of the Te NPs. Transmission electron microscopy showed that spherical nanoparticles without aggregation had the average size of 45.7 nm as determined by the laser scattering method. The energy dispersive X-ray pattern confirmed the presence of Te atoms without any impurities. A significant reduction was observed in group which received with or without Te NPs during propylthiouracil and cholesterol diet in compare with the control group which received just propylthiouracil and cholesterol. The levels of triglycerides also remarkably decrease ( <; 0.05) in mice given with intracellular Te NPs.
机译：高胆固醇血症是导致动脉粥样硬化和冠心病的重要危险因素。乳酸菌因其对血清胆固醇水平的有希望的作用而备受关注。碲（Te）是一种稀有元素，也因其生物学效应而引起了广泛关注。最近有一些关于Te对胆固醇含量的降低作用的报道。在这项研究中，PTCC 1058用于Te NP的细胞内生物合成。纯化的NP的紫外-可见光谱在214 nm处出现一个与Te NP的表面等离子体共振相关的峰。透射电子显微镜显示，没有聚集的球形纳米颗粒通过激光散射法测定的平均尺寸为45.7nm。能量色散X射线图证实了Te原子的存在而没有任何杂质。与仅接受丙基硫氧嘧啶和胆固醇的对照组相比，在丙硫尿嘧啶和胆固醇饮食期间接受或不接受Te NPs治疗的组明显减少。在给予细胞内Te NPs的小鼠中，甘油三酸酯的水平也显着降低（<; 0.05）。

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