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首页> 外文期刊>Nanobiotechnology, IET >Green synthesis of silver nanoparticles for selective toxicity towards cancer cells
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Green synthesis of silver nanoparticles for selective toxicity towards cancer cells

机译：银纳米粒子的绿色合成，对癌细胞具有选择性毒性

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Therapeutic applications of nanoparticles (NPs) are rapidly increasing for their utility in medicine, especially cancer therapy. The present study investigated the green synthesis of silver NPs (Ag NPs) of 10 nm size using and its preferential ability to kill cancerous human myeloblastic leukemic cells HL60 and cervical cancer cells HeLa as compared with normal peripheral blood mononuclear cells. DNA fragmentation study and annexin V marker fluorescence-activated cell sorting (FACS) analysis revealed the Ag NP-induced cell death is through apoptosis. Transmission electron micrographs have showed the endocytosis of Ag NPs into the nucleus. Ag NPs inhibited the lipid peroxidation-induced reactive oxygen species generation, thus preventing the irradiation-related carcinogenesis. This study suggested that a mechanism underlying the toxicity of Ag NPs towards cancer cells is due to DNA damage and apoptosis. The authors’ findings revealed the potential utility of as-prepared Ag NPs in the treatment of cancer as prophylactic agent with antioxidant property and chemotherapeutic agent for their selective toxicity to cancer cells.
机译：纳米颗粒（NPs）在医学上的应用正在迅速增加，尤其是在癌症治疗方面。本研究研究了使用10纳米大小的银纳米颗粒（Ag NPs）的绿色合成方法，以及与正常人外周血单个核细胞相比，它具有杀死癌性人类粒细胞白血病细胞HL60和宫颈癌细胞HeLa的优先能力。 DNA片段化研究和膜联蛋白V标记荧光激活细胞分选（FACS）分析表明，Ag NP诱导的细胞死亡是通过凋亡引起的。透射电子显微镜照片显示Ag NPs内吞进入细胞核。 Ag NPs抑制脂质过氧化诱导的活性氧的产生，从而防止了与辐射有关的致癌作用。这项研究表明，银纳米颗粒对癌细胞毒性的潜在机制是由于DNA损伤和细胞凋亡。作者的发现揭示了制备的Ag NPs在治疗癌症方面具有潜在的实用性，该NPs具有抗氧化作用和化学治疗剂对癌细胞的选择性毒性。

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