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Nanotransporters for Anticancer Drug Delivery

机译：用于转运抗癌药物的纳米转运蛋白

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摘要

Nanomedicine is a relatively new field of medicine aiming to overcome usual problems that appear in disease treatment. Natural or artificial nanodevices, with dimensions similar to those of biological molecules in human body, can carry drugs more efficiently and mostly with no side effects on healthy tissue than drugs alone. Nowadays, there is a huge interest in nanotechnology for detection, imaging and cancer treatment because cancer causes death of millions people every year. There are already some nanoparticle based drugs, mostly in liposomes, approved for clinical use or under clinical investigation. Many attempts are made to improve nanoparticles sizes, shapes and surface modifications that lead to prolongation of drug circulation in blood stream and targeting to cancer cells. Thus small molecules like polyethylene glycol and targeting ligands like folic acid, peptides, antibodies, aptamers and nucleic acids are bound on the surface of nanoparticles with the aim to increase specific cell uptake. Very promising are multifunctional nanoparticles that combine both diagnostic as well as delivery role together. In this chapter, we describe recent progress on utilization of different nanotransporters including dendrimers, micelles, liposomes, protein-based carriers, graphene, graphene oxide, carbon nanotubes, silica, gold and iron oxides nanoparticles, for transport of anticancer drugs.
机译：纳米医学是医学的一个相对较新的领域，旨在克服疾病治疗中常见的问题。天然或人工纳米装置的尺寸与人体中生物分子的尺寸相似，与单独使用药物相比，它可以更有效地携带药物，并且对健康组织几乎没有副作用。如今，对于纳米技术的检测，成像和癌症治疗引起了极大的兴趣，因为癌症每年导致数百万人死亡。已经有一些基于纳米颗粒的药物被批准用于临床或正在接受临床研究，这些药物大多在脂质体中。人们进行了许多尝试来改善纳米颗粒的尺寸，形状和表面修饰，从而延长药物在血液中的循环并靶向癌细胞。因此，诸如聚乙二醇的小分子和诸如叶酸，肽，抗体，适体和核酸的靶向配体被结合在纳米颗粒的表面上，以增加特异性细胞摄取。多功能纳米颗粒将诊断和递送功能结合在一起。在本章中，我们描述了利用不同的纳米转运体（包括树状聚合物，胶束，脂质体，基于蛋白质的载体，石墨烯，氧化石墨烯，碳纳米管，二氧化硅，金和氧化铁纳米颗粒）运输抗癌药物的最新进展。

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  • 来源
    《Nanotechnology research journal》 |2015年第1期|1-51|共51页
  • 作者

    Pavel Kopel; Dorota Wawrzak; Vedran Milosavljevic; Amitava Moulick; Marketa Vaculovicova; Rene Kizek; Vojtech Adam;

  • 作者单位

    Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic,Central European Institute of Technology, Brno University of Technology, Technicka, Brno, Czech Republic;

    Institute of Chemistry, Envoronmental Protection and Biotechnology, Jan Dlugosz University of Czestochowa, Czestochowa, Poland;

    Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic;

    Central European Institute of Technology, Brno University of Technology, Technicka, Brno, Czech Republic;

    Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic,Central European Institute of Technology, Brno University of Technology, Technicka, Brno, Czech Republic;

    Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic,Central European Institute of Technology, Brno University of Technology, Technicka, Brno, Czech Republic;

    Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic,Central European Institute of Technology, Brno University of Technology, Technicka, Brno, Czech Republic;

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