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Developments in Tissue Engineering Scaffolding Using an Electrospinning Process

机译：使用电纺工艺的组织工程支架的发展

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摘要

Electrospinning is a simple and efficient process in producing nanofibers. The use of an electrospinning process in fabricating tissue engineering scaffolds has received great attention in recent years due to its simplicity and ability to fabricate ultrafine nanofibers. Most of the recent progress in tissue engineering has embarked on the use of nanofibers as tissue engineering scaffolds. This is because nanofibers can replicate the structural design of natural human tissue at the nano-scale thus shortening the healing time. Although electrospinning is a simple process, there are still several parameters which need to be controlled or optimised in order to produce nanofibers with different characteristics. Different applications might require nanofibers with specific criteria to be produced. Hence, this review will reveal the fundamental working principles of electrospinning process and the effect of electrospinning process parameters towards the nanofibers morphology. Various polymeric materials and their composites/blends have been successfully electrospun for tissue engineering (TE) scaffolds and they have been tabulated. In many cases, secondary processes are also integrated with the electrospinning process so as to develop 3D TE scaffolds and overcome limitations in term of the nanofiber thickness.
机译：电纺丝是生产纳米纤维的简单有效的方法。近年来，由于静电纺丝工艺的简单性和制造超细纳米纤维的能力，在制备组织工程支架中使用静电纺丝工艺受到了极大的关注。组织工程学中的最新进展大部分已开始使用纳米纤维作为组织工程支架。这是因为纳米纤维可以在纳米尺度上复制天然人体组织的结构设计，从而缩短了愈合时间。尽管静电纺丝是一个简单的过程，但是仍然有一些参数需要控制或优化，以生产具有不同特性的纳米纤维。不同的应用可能需要生产具有特定标准的纳米纤维。因此，本综述将揭示静电纺丝工艺的基本工作原理以及静电纺丝工艺参数对纳米纤维形态的影响。各种聚合物材料及其复合物/共混物已成功地电纺成组织工程（TE）支架，并已制成表格。在许多情况下，次级工艺也与静电纺丝工艺集成在一起，以开发3D TE支架并克服纳米纤维厚度方面的限制。

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  • 来源
    《Nanotechnology research journal》 |2017年第3期|369-400|共32页
  • 作者

    Nor Hasrul Akhmal Ngadiman; M. Y. Noordin; Ani Idris; Denni Kurniawan; Ehsan Fallahiarezoudar; Izman Sudin;

  • 作者单位

    Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Johor, Malaysia;

    Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Johor, Malaysia;

    Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Johor, Malaysia,Institute of Bioproduct Development, Johor, Malaysia;

    Department of Mechanical Engineering, Curtin University, Sarawak, Malaysia;

    Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Johor, Malaysia;

    Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Johor, Malaysia;

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