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首页> 外文期刊>Nature >Complex pectin metabolism by gut bacteria reveals novel catalytic functions
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Complex pectin metabolism by gut bacteria reveals novel catalytic functions

机译：肠道细菌对果胶的复杂代谢显示出新的催化功能

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摘要

The metabolism of carbohydrate polymers drives microbial diversity in the human gut microbiota. It is unclear, however, whether bacterial consortia or single organisms are required to depolymerize highly complex glycans. Here we show that the gut bacterium Bacteroides thetaiotaomicron uses the most structurally complex glycan known: the plant pectic polysaccharide rhamnogalacturonan-II, cleaving all but 1 of its 21 distinct glycosidic linkages. The deconstruction of rhamnogalacturonan-II side chains and backbone are coordinated to overcome steric constraints, and the degradation involves previously undiscovered enzyme families and catalytic activities. The degradation system informs revision of the current structural model of rhamnogalacturonan-II and highlights how individual gut bacteria orchestrate manifold enzymes to metabolize the most challenging glycan in the human diet.
机译：碳水化合物聚合物的代谢驱动人体肠道菌群中的微生物多样性。但是，尚不清楚是否需要细菌聚生体或单个生物体来解聚高度复杂的聚糖。在这里，我们显示肠道细菌拟杆菌（the Bacteroides thetaiotaomicron）使用已知结构最复杂的聚糖：植物果胶多糖鼠李半乳糖醛酸聚糖-II，其21个不同的糖苷键中只有1个断裂。鼠李半乳糖醛酸聚糖-II侧链和主链的解构协调以克服空间限制，降解涉及以前未发现的酶家族和催化活性。该降解系统为修订鼠李糖半乳糖醛酸聚糖-II的当前结构模型提供了信息，并强调了个别肠道细菌如何协调多种酶来代谢人类饮食中最具挑战性的聚糖。

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  • 来源
    《Nature》 |2017年第7648期|65-70|共6页
  • 作者

    Ndeh Didier; Rogowski Artur; Cartmell Alan; Luis Ana S.; Basle Arnaud; Gray Joseph; Venditto Immacolata; Briggs Jonathon; Zhang Xiaoyang; Labourel Aurore; Terrapon Nicolas; Buffetto Fanny; Nepogodiev Sergey; Xiao Yao; Field Robert A.; Zhu Yanping; ONeill Malcolm A.; Urbanowicz Breeanna R.; York William S.; Davies Gideon J.; Abbott D. Wade; Ralet Marie-Christine; Martens Eric C.; Henrissat Bernard; Gilbert Harry J.;

  • 作者单位

    Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England;

    Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England|Megazyme Bray Co, Wicklow A98 YV29, Ireland;

    Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England;

    Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England;

    Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England;

    Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England;

    Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England;

    Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England;

    Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England;

    Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England;

    Aix Marseille Univ, CNRS, Architecture & Fonct Macromol Biol, F-13288 Marseille, France;

    INRA, UR Biopolymeres Interact Assemblages 1268, F-44300 Nantes, France|Univ Stellenbosch, Dept Viticulture & Oenol, Inst Wine Biotechnol, ZA-7602 Matieland, South Africa;

    John Innes Ctr, Dept Biol Chem, Norwich Res Pk, Norwich NR4 7UH, Norfolk, England;

    Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA;

    John Innes Ctr, Dept Biol Chem, Norwich Res Pk, Norwich NR4 7UH, Norfolk, England;

    Univ Georgia, Complex Carbohydrate Res Ctr, 315 Riverbend Rd, Athens, GA 30602 USA;

    Univ Georgia, Complex Carbohydrate Res Ctr, 315 Riverbend Rd, Athens, GA 30602 USA;

    Univ Georgia, Complex Carbohydrate Res Ctr, 315 Riverbend Rd, Athens, GA 30602 USA;

    Univ Georgia, Complex Carbohydrate Res Ctr, 315 Riverbend Rd, Athens, GA 30602 USA;

    Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England;

    Lethbridge Res Ctr, Lethbridge, AB T1J 4B1, Canada;

    INRA, UR Biopolymeres Interact Assemblages 1268, F-44300 Nantes, France;

    Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA;

    Aix Marseille Univ, CNRS, Architecture & Fonct Macromol Biol, F-13288 Marseille, France|INRA, USC AFMB 1408, F-13288 Marseille, France|King Abdulaziz Univ, Dept Biol Sci, Jeddah, Saudi Arabia;

    Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England;

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