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Special delivery for the gut

机译:肠的特别运送

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摘要

"Drugs don't work if people don't take them." That succinct analysis by former US surgeon general C. Everett Koop points the way towards the huge contribution that biomaterials technology can make to health care. The failure of patients to follow instructions for taking medication is a major barrier to effective clinical care. In developed nations, adherence to long-term therapies is only 50%, and it is much lower in developing countries and in people who take multiple drugs with complex dose regimens1. Medication non-adherence is estimated to cost more than US$100 billion in avoidable hospitalizations every year in the United States. Technologies that would enable extended drug release - lasting for up to several months -through the gastrointestinal (GI) tract could therefore radically improve delivery of medical therapies. This may be especially useful for patients in areas afflicted by war, regions with poor access to health care, patients suffering from psychiatric illness or dementia, and paediatric populations.
机译:“如果人们不服用药物,它们是行不通的。”美国前外科医生C. Everett Koop所作的简洁分析指出,生物材料技术可以为医疗保健做出巨大贡献。患者未能遵循服药说明是有效临床护理的主要障碍。在发达国家,对长期疗法的依从性仅为50%,在发展中国家和服用多种药物且剂量复杂的人群中则要低得多。据估计,在美国,不遵守药物治疗每年可避免的住院费用超过1000亿美元。因此,可以通过胃肠道延长药物释放(持续长达数月)的技术可以从根本上改善医学治疗的提供。这对于受战争困扰的地区,难以获得医疗服务的地区,患有精神疾病或痴呆症的患者以及儿科人群尤其有用。

著录项

  • 来源
    《Nature》 |2015年第7544期|s19-s19|共1页
  • 作者单位

    Massachusetts General Hospital and Harvard Medical School in Boston;

    Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology in Cambridge;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
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