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首页> 外文期刊>Nature >Prefrontal parvalbumin interneurons shape neuronal activity to drive fear expression
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Prefrontal parvalbumin interneurons shape neuronal activity to drive fear expression

机译：前额小白蛋白中间神经元塑造神经元活动以驱动恐惧表达

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摘要

Synchronization of spiking activity in neuronal networks is a fundamental process that enables the precise transmission of information to drive behavioural responses. In cortical areas, synchronization of principal-neuron spiking activity is an effective mechanism for information coding that is regulated by GABA (γ-aminobutyric acid)-ergic interneurons through the generation of neuronal oscillations. Although neuronal synchrony has been demonstrated to be crucial for sensory, motor and cognitive processing, it has not been investigated at the level of defined circuits involved in the control of emotional behaviour. Converging evidence indicates that fear behaviour is regulated by the dorsomedial prefrontal cortex(dmPFC). This control over fear behaviour relies on the activation of specific prefrontal projections to the basolateral complex of the amygdala (BLA), a structure that encodes associative fear memories. However, it remains to be established how the precise temporal control of fear behaviour is achieved at the level of prefrontal circuits. Here we use single-unit recordings and optogenetic manipulations in behaving mice to show that fear expression is causally related to the phasic inhibition of prefrontal parvalbumin interneurons (PVINs). Inhibition of PVIN activity disinhibits prefrontal projection neurons and synchronizes their firing by resetting local theta oscillations, leading to fear expression. Our results identify two complementary neuronal mechanisms mediated by PVINs that precisely coordinate and enhance the neuronal activity of prefrontal projection neurons to drive fear expression.
机译：神经元网络中尖峰活动的同步是一个基本过程，可实现信息的精确传输以驱动行为响应。在皮层区域，主要神经元突增活动的同步是信息编码的有效机制，该信息编码受GABA（γ-氨基丁酸）-能间神经元通过神经元振荡的产生调节。尽管已经证明神经元同步对于感觉，运动和认知过程至关重要，但尚未在涉及情绪行为控制的明确电路水平上对其进行研究。越来越多的证据表明，恐惧行为是由背侧前额叶皮层（dmPFC）调节的。对恐惧行为的这种控制依赖于杏仁核（BLA）基底外侧复合体的特定前额叶投射的激活，该结构编码相关的恐惧记忆。但是，如何建立在前额回路水平上的恐惧行为的精确时间控制还有待确定。在这里，我们使用行为小鼠中的单单元录音和光遗传学操作来显示恐惧表达与前额小白蛋白中间神经元（PVINs）的相位抑制有因果关系。 PVIN活性的抑制会抑制前额叶投射神经元，并通过重置局部theta振荡来同步其放电，从而导致恐惧表达。我们的研究结果确定了由PVIN介导的两种互补神经元机制，它们可以精确地协调和增强前额叶投射神经元的神经元活动，从而驱动恐惧表达。

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  • 来源
    《Nature》 |2014年第7481期|92-96|共5页
  • 作者

    Julien Courtin; Fabrice Chaudun; Robert R. Rozeske; Nikolaos Karalis; Cecilia Gonzalez-Campo; Helene Wurtz; Azzedine Abdi; Jerome Baufreton; Thomas C. M.Bienvenu; Cyril Herry;

  • 作者单位

    INSERM, Neurocentre Magendie, U862,146 Rue Leo-Saignat, Bordeaux 33077, France,University of Bordeaux, Neurocentre Magendie, U862,146 Rue Leo-Saignat, Bordeaux 33077, France;

    INSERM, Neurocentre Magendie, U862,146 Rue Leo-Saignat, Bordeaux 33077, France,University of Bordeaux, Neurocentre Magendie, U862,146 Rue Leo-Saignat, Bordeaux 33077, France;

    INSERM, Neurocentre Magendie, U862,146 Rue Leo-Saignat, Bordeaux 33077, France,University of Bordeaux, Neurocentre Magendie, U862,146 Rue Leo-Saignat, Bordeaux 33077, France;

    INSERM, Neurocentre Magendie, U862,146 Rue Leo-Saignat, Bordeaux 33077, France,University of Bordeaux, Neurocentre Magendie, U862,146 Rue Leo-Saignat, Bordeaux 33077, France;

    INSERM, Neurocentre Magendie, U862,146 Rue Leo-Saignat, Bordeaux 33077, France,University of Bordeaux, Neurocentre Magendie, U862,146 Rue Leo-Saignat, Bordeaux 33077, France;

    INSERM, Neurocentre Magendie, U862,146 Rue Leo-Saignat, Bordeaux 33077, France,University of Bordeaux, Neurocentre Magendie, U862,146 Rue Leo-Saignat, Bordeaux 33077, France;

    University of Bordeaux, Institut des Maladies Neurodegeneratives, UMR 5293, Bordeaux F-33000, France,CNRS, Institut des Maladies Neurodegeneratives, UMR 5293, Bordeaux F-33000, France;

    University of Bordeaux, Institut des Maladies Neurodegeneratives, UMR 5293, Bordeaux F-33000, France,CNRS, Institut des Maladies Neurodegeneratives, UMR 5293, Bordeaux F-33000, France;

    INSERM, Neurocentre Magendie, U862,146 Rue Leo-Saignat, Bordeaux 33077, France,University of Bordeaux, Neurocentre Magendie, U862,146 Rue Leo-Saignat, Bordeaux 33077, France;

    INSERM, Neurocentre Magendie, U862,146 Rue Leo-Saignat, Bordeaux 33077, France,University of Bordeaux, Neurocentre Magendie, U862,146 Rue Leo-Saignat, Bordeaux 33077, France;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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