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A is for immunity

机译:A代表免疫力

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摘要

Vitamin A has fundamental roles in embryonic development, reproduction, bone metabolism, skin homeostasis and vision. Therefore, vitamin A deficiency has profound effects on the fetus and in early childhood, and is responsible for the high prevalence of childhood blindness and for many deaths in regions plagued with malnutrition. Another major role for vitamin A is in immunity - this has been known about for more than 40 years, but only fully investigated in the past decade. On page 123 of this issue, van de Pavert et al. report that vitamin A provided by a mother mouse to her fetus is required for the offspring to develop full-size lymph nodes, the organs in which adaptive immune responses are generated. As a consequence, newborn mice that have not received optimal vitamin A exposure in utero are more susceptible to infection.
机译:维生素A在胚胎发育,生殖,骨骼代谢,皮肤稳态和视觉方面具有基本作用。因此,维生素A缺乏症对胎儿和幼儿期有深远的影响,并导致儿童盲症的高患病率和营养不良地区的许多死亡。维生素A的另一个主要作用是提高免疫力-众所周知已有40多年了,但在过去的十年中才进行了充分研究。在第123页上,van de Pavert等人。报告指出,母鼠向胎儿提供的维生素A是子代发育成全尺寸淋巴结所必需的,而淋巴结是在器官中产生适应性免疫反应的。结果,未在子宫内接受最佳维生素A暴露的新生小鼠更容易受到感染。

著录项

  • 来源
    《Nature》 |2014年第7494期|47-48|共2页
  • 作者

    GERARD EBERL;

  • 作者单位

    Lymphoid Tissue Development Unit, Institut Pasteur, 75724 Paris, France;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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