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Mammalian watchdog targets bacteria

机译：哺乳动物看门狗针对细菌

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摘要

All animals, including humans, are exposed daily to a variety of chemicals in the air, water and food. Some of these carry valuable information about the host's environment, such as the presence of food, predators, members of the opposite sex or, in the case of hyenas, members of the clan to which they belong1. But others are toxic and must be eliminated. Among several mechanisms for detecting and responding to these environmental cues is the aryl hydrocarbon receptor (AhR) protein, which can facilitate the biotransformation and elimination of toxic compounds encountered in the environment. On page 387 of this issue, Moura-Alves et al. report that bacterial compounds known as phenazines also act as potential AhR ligands, and that recognition of these virulence factors by AhR contributes to host defence against invading microbial pathogens.
机译：包括人类在内的所有动物每天都要暴露在空气，水和食物中的各种化学物质中。其中一些携带有关寄主环境的有价值的信息，例如食物的存在，掠食者，异性成员，或者在鬣狗的情况下，是其所属氏族的成员1。但是其他有毒，必须消除。在检测和响应这些环境提示的几种机制中，有芳基烃受体（AhR）蛋白，它可以促进环境中遇到的有毒化合物的生物转化和消除。在此问题的第387页上，Moura-Alves等人。报告指出被称为吩嗪的细菌化合物也可以作为潜在的AhR配体，而AhR对这些毒力因子的识别有助于宿主防御入侵的微生物病原体。

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  • 来源
    《Nature》 |2014年第7515期|377-378|共2页
  • 作者

    PARAG KUNDU; SVEN PETTERSSON;

  • 作者单位

    Lee Kong Chian School of Medicine and Environmental Life Sciences Engineering, Nanyang Technological University, Singapore 637551;

    Lee Kong Chian School of Medicine and Environmental Life Sciences Engineering, Nanyang Technological University, Singapore 637551, National Cancer Center, Singapore General Hospital Singapore Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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