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Cloning human embryos

机译:克隆人类胚胎

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摘要

The birth of Dolly the sheep in 1996 produced great excitement among researchers. This first cloned mammal had been created by introducing the nucleus of a somatic (non-germ) cell into an egg cell from which the genomic DNA had been removed, and transferring the resulting embryo into a foster mother. One implication of this achievement was that similarly cloned embryos could be used to produce stem cells that would be genetically identical to the cells of the somatic-cell donor, so that if these stem cells, or cells or tissues derived from them, were transplanted into the donor for treatment purposes they would not be rejected by the donors immune system. In the years that followed, this technique of somatic-cell nuclear transfer (SCNT) was successfully used to produce stem cells from cloned mouse embryos, but all attempts in humans had failed — until the publication of a study in Cell by Tachibana et al.
机译:绵羊多莉(Dolly)于1996年出生,这引起了研究人员的极大兴趣。通过将体细胞(非生殖细胞)的细胞核引入已去除基因组DNA的卵细胞中,然后将所得的胚胎转移到寄养母亲中,从而创建了第一个克隆的哺乳动物。这一成就的一个含义是,可以使用相似克隆的胚胎生产与体细胞供体细胞遗传相同的干细胞,因此,如果将这些干细胞或衍生自它们的细胞或组织移植到供体出于治疗目的,它们不会被供体免疫系统拒绝。在随后的几年中,这种体细胞核转移技术(SCNT)被成功地用于从克隆的小鼠胚胎中产生干细胞,但人类的所有尝试都以失败告终-直到Tachibana等人在《细胞》杂志上发表了一项研究。

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  • 来源
    《Nature》 |2013年第7453期|174-175|共2页
  • 作者单位

    in the department of Anatomy and Embryology, Leiden University Medical Centre, 2300 RC Leiden,the Netherlands;

    in the department of Farm Animal Health,Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, the Netherlands;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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