首页> 外文期刊>Nature >Lipid switches and traffic control
【24h】

Lipid switches and traffic control

机译:脂质开关和交通控制

获取原文
获取原文并翻译 | 示例
           

摘要

Not unlike the number of commuters driving into a city during the morning rush hour, the volume of traffic moving into a cell by the process of endocytosis is some 10 times higher than that of biosyn-thetic vesicles moving out. However, unlike motor vehicles, endocytic vesicles rapidly undergo fusion and fission to allow sorting of their cargo. So for fidelity of transport along this entangled highway, nascent vesicles must instantly acquire a membrane identity that is distinct from that of the membrane from which they have emerged. Different species of lipids called phosphatidylinositol phosphates mark specific membrane compartments. In a study in this issue, Posor et aV (page 233) describe a mechanism for spatially and temporally regulated interconversion of these lipids during the maturation of vesicles that are involved in clathrin-mediated endocytosis - the main pathway for the internalization of nutrients and signalling receptors.
机译:与早上高峰时段开车进入城市的通勤者一样,通过内吞作用进入细胞的交通量大约是生物合成囊泡排出的交通量的10倍。然而,与机动车辆不同,内吞囊泡会迅速发生融合和裂变,以便对其货物进行分类。因此,为了沿着这条纠缠的公路保真运输,新生的囊泡必须立即获得与已经出现的膜不同的膜特性。称为磷脂酰肌醇磷酸酯的不同种类的脂质标记特定的膜区室。在该问题的一项研究中,Posor等人(第233页)描述了在与网格蛋白介导的内吞作用有关的囊泡成熟过程中,这些脂质在空间和时间上调控的相互转化的机制-营养素内在化和信号传导的主要途径受体。

著录项

  • 来源
    《Nature》 |2013年第7457期|161-162|共2页
  • 作者单位

    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas,Texas 75390-9039, USA;

    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas,Texas 75390-9039, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号