Targeting a vicious cycle

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Targeting a vicious cycle

机译：针对恶性循环

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Cancer cells proliferate by sending the cell cycle into overdrive, but early attempts to target the cell cycle with drugs were marred by problems with toxicity. Now two groups show that shutting down cell-cycle proteins called D-type cyclins seems to stop tumour growth without affecting normal tissue.

机译：癌细胞通过使细胞周期过度运转而增殖，但是早期针对药物靶向细胞周期的尝试因毒性问题而受损。现在有两组显示，关闭称为D型细胞周期蛋白的细胞周期蛋白似乎可以在不影响正常组织的情况下停止肿瘤的生长。

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《Nature》 |2012年第7421期|p.449|共1页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. mTOR inhibitor and bone-targeted drugs break the vicious cycle between clear-cell renal carcinoma and osteoclasts in an in vitro co-culture model [J] . Chiara Spadazzi, Federica Recine, Laura Mercatali, Journal of Bone Oncology . 2019,第4期

机译：在体外共培养模型中，mTOR抑制剂和靶向骨的药物打破了透明细胞肾癌和破骨细胞之间的恶性循环
2. HIV and the Gut Microbiota, Partners in Crime: Breaking the Vicious Cycle to Unearth New Therapeutic Targets [J] . Kisha Vyhoh, Mohammad-Ali Jenabian, Vikram Mehraj, Clinical & developmental immunology. . 2015,第1期

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3. Dupuytren's disease therapy: targeting the vicious cycle of myofibroblasts? [J] . Expert opinion on therapeutic targets . 2015,第12期

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4. MODELING THE DYNAMICS OF VICIOUS CYCLES INVOLVED IN HEART-RESPIRATORY FAILURE [C] . Sema Comez, Yaman Barlas, Aybek Korugan International Conference of the System Dynamics Society . 2021

机译：建模心脏呼吸衰竭涉及的恶性循环动态
5. Application of a biomechanical finite element spine model to the vicious cycle scoliosis growth theory: Evaluation of improved FEA geometry and material assignment [D] . Fok, Jonathan Winfield 2009

机译：生物力学有限元脊柱模型在恶性循环脊柱侧弯生长理论中的应用：改进的有限元分析几何和材料分配的评估
6. mTOR inhibitor and bone-targeted drugs break the vicious cycle between clear-cell renal carcinoma and osteoclasts in an in vitro co-culture model [O] . Chiara Spadazzi, Federica Recine, Laura Mercatali, 2019

机译：在体外共培养模型中mTOR抑制剂和靶向骨的药物打破了透明细胞肾癌和破骨细胞之间的恶性循环
7. mTOR inhibitor and bone-targeted drugs break the vicious cycle between clear-cell renal carcinoma and osteoclasts in an in vitro co-culture model [O] . Chiara Spadazzi, Federica Recine, Laura Mercatali, 2019

机译：MTOR抑制剂和骨靶向药物在体外共培养模型中打破了透明细胞肾癌和骨核苷酸之间的恶性循环

Targeting a vicious cycle

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