Mice and men show the way

Evdokia Anagnostou

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Mice and men show the way

机译：老鼠和男人指引路

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The translation of findings from genomics and animal studies into therapies for neurodevelopmental disorders, such as autism, is still in its infancy. One promising approach is to align animal studies with clinical trials, as Henderson et al.' and Berry-Kravis et al.~2 report in Science Tmnslational Medicine. Their data suggest that the drug arbaclofen (STX209) reverses symptoms related to fragile X syndrome in a mouse model of the disorder. It also promotes social engagement in patients with fragile X syndrome who show marked social impairment.

机译：从基因组学和动物研究的发现到神经发育障碍（例如自闭症）的治疗方法的转化仍处于起步阶段。如Henderson等人所述，一种有前途的方法是使动物研究与临床试验保持一致。 Berry-Kravis等人〜2在《科学医学杂志》上发表了论文。他们的数据表明，阿巴洛芬（STX209）药物可在该疾病的小鼠模型中逆转与脆性X综合征相关的症状。它也促进了表现出明显社交障碍的脆性X综合征患者的社交参与。

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来源
《Nature》 |2012年第7423期|p.196-197|共2页
作者
Evdokia Anagnostou;
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作者单位

Bloorview Research Institute, Department of Pediatrics, University of Toronto, Toronto, Ontario M4G 1R8, Canada;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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Mice and men show the way

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