The cancer connection

REUBEN J. SHAW

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The cancer connection

机译：癌症联系

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A tumour-suppressor protein that mediates DNA repair and has ties with a metabolic disorder1 - this might sound far-fetched. But in fact the reported link between responsiveness to metformin and a cancer gene is not without precedent. Previous work has shown that activation of AMPK by metformin requires the activity of the kinase enzyme LKB1. The gene encoding LKB1 was originally identified for causing an inherited cancer disorder, and is one of the most commonly mutated genes in human lung cancer6. Animal studies also point to a role for this gene in a variety of spontaneously arising cancers. Notably, deletion of Lkbl in mouse liver leads to loss of AMPK activity in that organ and to the development of metabolic dysfunction, including hyperglycaemia and hepatic steatosis - symptoms resembling those of type 2 diabetes7. Furthermore, a genetic survey revealed that DNA-base variations in LKB1 affect how women with poly-cystic ovary syndrome respond to treatment with metformin.

机译：一种介导DNA修复并与代谢疾病有关的肿瘤抑制蛋白1-听起来可能牵强。但实际上，已报道的对二甲双胍反应性与癌症基因之间的联系并非没有先例。先前的工作表明，二甲双胍激活AMPK需要激酶LKB1的活性。最初鉴定出编码LKB1的基因可引起遗传性癌症疾病，并且是人类肺癌中最常见的突变基因之一6。动物研究也指出了该基因在多种自发性癌症中的作用。值得注意的是，小鼠肝脏中Lkb1的缺失导致该器官AMPK活性的丧失，并导致代谢功能障碍的发展，包括高血糖症和肝脂肪变性-类似于2型糖尿病的症状。此外，一项遗传调查显示，LKB1中的DNA碱基变化影响多囊卵巢综合征女性对二甲双胍治疗的反应。

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来源
《Nature》 |2011年第7334期|p.338-339|共2页
作者
REUBEN J. SHAW;
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作者单位

Molecular and Cell Biology Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, Lajolla, California 92037, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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1. University of Hawai‘i Cancer Center Connection: The Vital Role of Cancer Registries in the Recruitment of an Understudied Minority Population into a Breast Cancer Study: Breast Cancer Risk Model for the Pacific [J] . Rachael T Leon Guerrero, Grazyna Badowski, Alisha Yamanaka, Hawaii medical journal . 2014,第10期

机译：夏威夷大学癌症中心联系：癌症登记册在招募被调查的少数民族人口纳入乳腺癌研究中的重要作用：太平洋地区的乳腺癌风险模型
2. 100 volumes of the Bulletin du Cancer: More than a century in connection with the French Cancer Society [100 volumes du Bulletin du Cancer: plus d'un siècle en lien avec la Société fran?aise du cancer] [J] . Harel-BellanA., MartyM. Bulletin du Cancer: Journal de l'Association Francaise pour l'Etude du Cancer . 2013,第2期

机译：《癌症通讯》 100卷：与法国癌症学会有关的一个世纪以上[关于癌症通讯100册：与法国社会研究协会相关的一个世纪以上的历史]
3. Lung cancer which accompanies anomalous venous connections, pulmonary and systemic-partial anomalous pulmonary venous connection and persistent left superior vena cava: report of 2 cases [J] . Yamada M, Koshika M, Goto S, 胸部外科 . 2005,第5期

机译：伴有静脉异常连接，肺和全身部分异常的肺静脉连接以及持续性左上腔静脉伴发的肺癌：2例报告
4. Using bioinformatics methods to explore the connections between expression and subcellular localization of proteins and gastric cancer progression [C] . Zhenying Tang, Ming Xiao, Senyi Deng, IEEE International Conference on Bioinformatics and Biomedicine . 2020

机译：使用生物信息学方法探讨蛋白质表达与亚细定位的连接和胃癌进展
5. Couple connection and cancer: Understanding the mechanisms of partner support for women with breast cancer. [D] . Pukay-Martin, Nicole D. 2010

机译：夫妻联系与癌症：了解乳腺癌女性伴侣支持的机制。
6. Improving clinical management of colon cancer through CONNECTION a nation-wide colon cancer registry and stratification effort (CONNECTION II trial): rationale and protocol of a single arm intervention study [O] . I. van den Berg, S. van de Weerd, J. M. L. Roodhart, 2020

机译：通过连接全国冒号癌登记和分层努力提高结肠癌的临床管理（连接II试验）：单一臂干预研究的理由和议定书
7. Improving clinical management of colon cancer through CONNECTION, a nation-wide colon cancer registry and stratification effort (CONNECTION II trial): rationale and protocol of a single arm intervention study [O] . I. van den Berg, S. van de Weerd, J. M. L. Roodhart, 2020

机译：通过连接，全国冒号癌登记和分层努力提高结肠癌的临床管理（连接II试验）：单一臂干预研究的理由和议定书

The cancer connection

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