The Cancer Genome

Michael R. Stratton; Peter J. Campbell; P. Andrew Futreal

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The Cancer Genome

机译：癌症基因组

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All cancers arise as a result of changes that have occurred in the DNA sequence of the genomes of cancer cells. Over the past quarter of a century much has been learnt about these mutations and the abnormal genes that operate in human cancers. We are now, however, moving into an era in which it will be possible to obtain the complete DNA sequence of large numbers of cancer genomes. These studies will provide us with a detailed and comprehensive perspective on how individual cancers have developed.

机译：所有癌症的发生都是癌细胞基因组DNA序列发生变化的结果。在过去的25年中，人们已经学到了很多有关这些突变以及在人类癌症中起作用的异常基因的信息。但是，我们现在正进入一个时代，在该时代将有可能获得大量癌症基因组的完整DNA序列。这些研究将为我们提供关于个体癌症如何发展的详细而全面的观点。

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来源
《Nature》 |2009年第7239期|719-724|共6页
作者
Michael R. Stratton; Peter J. Campbell; P. Andrew Futreal;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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2. A systems approach defining constraints of the genome architecture on lineage selection and evolvability during somatic cancer evolution A systems approach defining constraints of the genome architecture on lineage selection and evolvability during somatic cancer evolution A systems approach defining constraints of the genome architecture on lineage selection and evolvability during somatic cancer evolution [J] . Ole Nordhoff, Albert Rübben Biology Open . 2013,第1期

机译：一种定义体细胞癌进化过程中基因组结构对谱系选择和可进化性的约束的系统方法一种定义体细胞癌进化过程中基因组结构对谱系选择和可进化性的约束的系统方法一种定义基因组体系结构关于谱系选择和可进化性的约束的系统方法在体癌演变过程中
3. Genome-wide analysis of gynecologic cancer: The Cancer Genome Atlas in ovarian and endometrial cancer [J] . Iijima Moito, Banno Kouji, Okawa Ryuichiro, Oncology letters . 2017,第3aPta1期

机译：妇科癌症的基因组分析：卵巢和子宫内膜癌中的癌症基因组图集
4. DO CANCER CLINICAL TRIAL POPULATIONS TRULY REPRESENT CANCER PATIENTS? A COMPARISON OF OPEN CLINICAL TRIALS TO THE CANCER GENOME ATLAS [C] . NOPHARGEIFMAN, ATUL J.BUTTE Pacific Symposium on Biocomputing . 2016

机译：癌症临床试验群体真正代表癌症患者吗？对癌症基因组阿特拉斯公开临床试验的比较
5. Pairwise Ranking and Removal Network Analysis of Genome-Wide Gene Expression Data: Theory, a New Algorithm, and Analysis of Data from the Cancer Genome Atlas [D] . Sainath Madduri, Abishek. 2017

机译：全基因组表达数据的成对排序和去除网络分析：理论，新算法和癌症基因组图谱的数据分析
6. A Gene Gravity Model for the Evolution of Cancer Genomes: A Study of 3000 Cancer Genomes across 9 Cancer Types [O] . Feixiong Cheng, Chuang Liu, Chen-Ching Lin, 2015

机译：癌症基因组进化的基因重力模型：对9种癌症类型的3000个癌症基因组的研究
7. A Gene Gravity Model for the Evolution of Cancer Genomes: A Study of 3,000 Cancer Genomes across 9 Cancer Types. [O] . Feixiong Cheng, Chuang Liu, Chen-Ching Lin, 2015

机译：癌症基因组进化的基因重力模型：对9种癌症类型的3,000个癌症基因组的研究。

The Cancer Genome

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