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首页> 外文期刊>Nature >Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation
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Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation

机译：Xist RNA独立引发的小鼠印迹X染色体失活的证据

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摘要

XX female mammals undergo transcriptional silencing of most genes on one of their two X chromosomes to equalize X-linked gene dosage with XY males in a process referred to as X-chromosome inactivation (XCI). XCI is an example of epigenetic regulation. Once enacted in individual cells of the early female embryo, XCI is stably transmitted such that most descendant cells maintain silencing of that X chromosome. In eutherian mammals, XCI is thought to be triggered by the expression of the non-coding Xist RNA from the future inactive X chromosome (Xi); Xist RNA in turn is proposed to recruit protein complexes that bring about heterochromatinization of the Xi. Here we test whether imprinted XCI, which results in preferential inactivation of the paternal X chromosome (Xp), occurs in mouse embryos inheriting an Xp lacking Xist. We find that silencing of Xp-linked genes can initiate in the absence of paternal Xist; Xistis, however, required to stabilize silencing along the Xp. Xp-linked gene silencing associated with mouse imprinted XCI, therefore, can initiate in the embryo independently of Xist RNA.
机译：XX雌性哺乳动物在其两个X染色体之一上经历了大多数基因的转录沉默，以称为X染色体失活（XCI）的过程使X连锁基因的剂量与XY雄性相等。 XCI是表观遗传调控的一个例子。一旦在早期雌性胚胎的单个细胞中起作用，XCI就会稳定地传播，以使大多数后代细胞保持该X染色体的沉默。在欧亚哺乳动物中，XCI被认为是由来自未来无活性X染色体（Xi）的非编码Xist RNA的表达触发的。反过来，提出了Xist RNA来募集引起Xi异染色质化的蛋白质复合物。在这里，我们测试印迹XCI是否会导致遗传性Xp缺乏的Xp小鼠胚胎中发生，从而导致父系X染色体（Xp）优先失活。我们发现Xp连锁基因的沉默可以在没有父亲Xist的情况下启动。但是，Xistis需要稳定Xp上的沉默。因此，与小鼠印迹XCI相关的Xp连锁基因沉默可以独立于Xist RNA在胚胎中启动。

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  • 来源
    《Nature》 |2009年第7255期|647-651|共5页
  • 作者

    Sundeep Kalantry; Sonya Purushothaman; Randall Bryant Bowen; Joshua Starmer; Terry Magnuson;

  • 作者单位

    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA;

    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA;

    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA;

    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA;

    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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