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A new class of homoserine lactone uorum-sensing signals

机译：一类新的高丝氨酸内酯群体感应信号

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Quorum sensing is a term used to describe cell-to-cell communication that allows cell-density-dependent gene expression. Many bacteria use acyl-homoserine lactone (acyl-HSL) synthases to generate fatty acyl-HSL quorum-sensing signals, which function with signal receptors to control expression of specific genes. The fatty acyl group is derived from fatty acid biosynthesis and provides signal specificity, but the variety of signals is limited. Here we show that the photosynthetic bacterium Rhodopseudomonas palustris uses an acyl-HSL synthase to produce p-coumaroyl-HSL by using environmental p-coumaric acid rather than fatty acids from cellular pools. The bacterium has a signal receptor with homology to fatty acyl-HSL receptors that responds to p-coumaroyl-HSL to regulate global gene expression. We also found that p-coumaroyl-HSL is made by other bacteria including Bradyrhizobium sp. and Silicibacter pomeroyi. This discovery extends the range of possibilities for acyl-HSL quorum sensing and raises fundamental questions about quorum sensing within the context of environmental signalling.
机译：群体感应是一个术语，用于描述允许细胞密度依赖性基因表达的细胞间通信。许多细菌使用酰基高丝氨酸内酯（酰基-HSL）合酶来生成脂肪酰基-HSL群体感应信号，该信号与信号受体一起起作用以控制特定基因的表达。脂肪酰基衍生自脂肪酸生物合成并提供信号特异性，但信号种类有限。在这里，我们显示光合细菌大红假单胞菌利用酰基-HSL合酶通过使用环境对-香豆酸而不是来自细胞池的脂肪酸来生产对-香豆酰-HSL。该细菌具有与脂肪酰基-HSL受体同源的信号受体，该信号对p-香豆酰基-HSL作出反应，以调节整体基因表达。我们还发现，p-香豆酰-HSL是由其他细菌制成的，包括Bradyrhizobium sp。和Somericbacter pomeroyi。这一发现扩展了酰基-HSL群体感应的可能性范围，并提出了有关环境信号环境下群体感应的基本问题。

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