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Lack of long-term cortical reorganization after macaque retinal lesions

机译：猕猴视网膜病变后缺乏长期的皮质重组

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Several aspects of cortical organization are thought to remain plastic into adulthood, allowing cortical sensorimotor maps to be modified continuously by experience. This dynamic nature of cortical circuitry is important for learning, as well as for repair after injury to the nervous system. Electrophysiology studies suggest that adult macaque primary visual cortex (V1) undergoes large-scale reorganization within a few months after retinal lesioning, but this issue has not been conclusively settled. Here we applied the technique of functional magnetic resonance imaging ( fMRI) to detect changes in the cortical topography of macaque area V1 after binocular retinal lesions. fMRI allows non-invasive, in vivo, long-term monitoring of cortical activity with a wide field of view, sampling signals from multiple neurons per unit cortical area. We show that, in contrast with previous studies, adult macaque V1 does not approach normal responsivity during 7.5 months of follow-up after retinal lesions, and its topography does not change. Electrophysiology experiments corroborated the fMRI results. This indicates that adult macaque V1 has limited potential for reorganization in the months following retinal injury.
机译：皮质组织的几个方面被认为可以保持成年后的可塑性，从而使皮质感觉运动图可以根据经验不断进行修改。皮质电路的这种动态特性对于学习以及神经系统受伤后的修复都很重要。电生理研究表明，成年猕猴初级视皮层（V1）在视网膜病变后的几个月内经历了大规模的重组，但是这个问题尚未得到最终解决。在这里，我们应用了功能磁共振成像（fMRI）技术来检测双眼视网膜病变后猕猴V1区的皮质地形变化。 fMRI可以在广阔的视野范围内对皮层活动进行无创的，长期的体内监测，可以从每个皮层区域的多个神经元中采样信号。我们显示，与以前的研究相比，成年猕猴V1在视网膜病变后7.5个月的随访期间没有达到正常的反应能力，并且其地形也没有改变。电生理实验证实了功能磁共振成像的结果。这表明成年猕猴V1在视网膜损伤后的几个月内重组的潜力有限。

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