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首页> 外文期刊>Nature >Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase
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Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase

机译：两种有丝分裂驱动蛋白在后期共同驱动姐妹染色单体分离

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摘要

During anaphase identical sister chromatids separate and move towards opposite poles of the mitotic spindle. In the spindle, kinetochore microtubules have their plus ends embedded in the kinetochore and their minus ends at the spindle pole. Two models have been proposed to account for the movement of chromatids during anaphase. In the 'Pac-Man' model, kinetochores induce the depolymerization of kinetochore microtubules at their plus ends, which allows chromatids to move towards the pole by 'chewing up' microtubule tracks. In the 'poleward flux' model, kinetochores anchor kinetochore microtubules and chromatids are pulled towards the poles through the depolymerization of kinetochore microtubules at the minus ends. Here, we show that two functionally distinct microtubule-destabilizing KinI kinesin enzymes (so named because they possess a kinesin-like ATPase domain positioned internally within the polypeptide) are responsible for normal chromatid-to-pole motion in Drosophila. One of them, KLP59C, is required to depolymerize kinetochore microtubules at their kinetochore-associated plus ends, thereby contributing to chromatid motility through a Pac-Man-based mechanism. The other, KLP10A, is required to depolymerize microtubules at their pole-associated minus ends, thereby moving chromatids bv means of poleward flux.
机译：在后期，相同的姐妹染色单体分离并移向有丝分裂纺锤体的相反两极。在纺锤体中，线粒体微管的正端嵌入在线粒体中，负端在纺锤体极上。已经提出了两种模型来说明后期染色单体的运动。在“吃豆人”模型中，动粒体在其正端诱导动粒微管解聚，这允许染色单体通过“咀嚼”微管轨道向极点移动。在“极向通量”模型中，动粒体锚定线粒体微管和染色单体通过在负端的线粒体微管解聚而被拉向两极。在这里，我们显示了两个功能不同的微管破坏性KinI驱动蛋白酶（之所以命名，是因为它们具有位于多肽内部的驱动蛋白样ATPase域），是果蝇中正常染色单体到极子运动的原因。其中之一，KLP59C，需要在其与线粒体相关的正端解聚线粒体微管，从而通过基于Pac-Man的机制促进染色单体的运动。另一个需要KLP10A，以使微管在其与极相关的负端解聚，从而通过极向通量的方式移动染色单体。

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