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首页> 外文期刊>Nature >Differentiating germ cells can revert into functional stem cells in Drosophila melanogaster ovaries
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Differentiating germ cells can revert into functional stem cells in Drosophila melanogaster ovaries

机译：分化的生殖细胞可在果蝇卵巢中恢复为功能性干细胞

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摘要

Many tissues including blood, skin, gut and germ cells are continuously maintained by tissue stem cells. Under certain conditions, however, other organs can undergo repair using stem-cell-like progenitors generated by cell de-differentiation. Cell fates have been broadened experimentally, but mechanisms allowing de-differentiation to a stem cell state are poorly known. Germline stem cells begin to differentiate by forming interconnected germ cell cysts (cystocytes), and under certain conditions male mouse cystocytes have been postulated to revert into functional progenitors. Here we report that four- and eight-cell Drosophila germline cystocytes generated either in second instar larval ovaries or in adults over-producing the BMP4-like stem cell signal Decapentaplegic efficiently convert into single stem-like cells. These de-differentiated cells can develop into functional germline stem cells and support normal fertility. Our results show that cystocytes represent a relatively abundant source of regenerative precursors that might help replenish germ cells after depletion by genotoxic chemicals, radiation or normal ageing. More generally, Drosophila cystocytes now provide a system for studying de-differentiation and its potential as a source of functional stem cells.
机译：许多组织包括血液，皮肤，肠道和生殖细胞都由组织干细胞持续维持。然而，在某些条件下，其他器官可以使用由细胞去分化产生的干细胞样祖细胞进行修复。实验已经拓宽了细胞命运，但是使去分化为干细胞状态的机制知之甚少。生殖系干细胞开始通过形成相互连接的生殖细胞囊肿（膀胱细胞）而分化，并且在某些条件下，已假定雄性小鼠囊状细胞可恢复为功能性祖细胞。在这里我们报告说，在第二龄幼虫卵巢中或在过量产生BMP4类干细胞信号Decapentaplegic的成年人中产生的四细胞和八细胞果蝇种系囊细胞有效地转化为单个干细胞样细胞。这些去分化的细胞可以发育成功能性种系干细胞，并支持正常的生育能力。我们的研究结果表明，膀胱细胞代表了相对丰富的再生前体来源，在被遗传毒性化学物质，辐射或正常衰老耗尽后，可能有助于补充生殖细胞。更一般地，果蝇囊细胞现在提供了研究去分化及其作为功能性干细胞来源的潜力的系统。

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  • 来源
    《Nature》 |2004年第6982期|p.564-569|共6页
  • 作者

    Toshie Kai; Allan Spradling;

  • 作者单位

    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, 115 W. University Parkway, Baltimore, Maryland 21210, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 自然科学总论;
  • 关键词

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