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Evidence for dynamically organized modularity in the yeast protein-protein interaction network

机译：酵母蛋白质-蛋白质相互作用网络中动态组织模块化的证据

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摘要

In apparently scale-free protein-protein interaction networks, or 'interactome' networks(1,2), most proteins interact with few partners, whereas a small but significant proportion of proteins, the 'hubs', interact with many partners. Both biological and nonbiological scale-free networks are particularly resistant to random node removal but are extremely sensitive to the targeted removal of hubs(1). A link between the potential scale-free topology of interactome networks and genetic robustness(3,4) seems to exist, because knockouts of yeast genes(5,6) encoding hubs are approximately threefold more likely to confer lethality than those of non-hubs(1). Here we investigate how hubs might contribute to robustness and other cellular properties for protein protein interactions dynamically regulated both in time and in space. We uncovered two types of hub: 'party' hubs, which interact with most of their partners simultaneously, and 'date' hubs, which bind their different partners at different times or locations. Both in silico studies of network connectivity and genetic interactions described in vivo support a model of organized modularity in which date hubs organize the proteome, connecting biological processes-or modules(7)-to each other, whereas party hubs function inside modules.
机译：在看似无尺度的蛋白质-蛋白质相互作用网络或“相互作用组”网络（1,2）中，大多数蛋白质与很少的伴侣相互作用，而一小部分却占很大比例的蛋白质“集线器”与许多伴侣相互作用。生物和非生物无标​​度网络对随机节点删除特别有抵抗力，但对目标集线器删除极为敏感（1）。相互作用基因组网络的潜在无尺度拓扑结构和遗传稳健性之间似乎存在联系（3,4），因为敲除编码集线器的酵母基因（5,6）的基因敲除致死力的可能性比非hubs高大约三倍（1）。在这里，我们研究集线器可能如何增强鲁棒性和其他细胞特性，从而在时间和空间上动态调节蛋白质相互作用。我们发现了两种类型的集线器：“派对”集线器，它们与大多数伙伴同时进行交互；以及“约会”集线器，它们在不同时间或位置绑定其不同的伙伴。体内描述的网络连通性和遗传相互作用的计算机模拟研究均支持一种有组织的模块化模型，在该模型中，日期中心组织蛋白质组，将生物过程（或模块）（7）相互连接，而聚会中心在模块内部起作用。

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