The past 50 years have seen a transformation in the practice of psychiatry. The emphasis has moved from psychotherapy with a limited repertoire of drugs that were used only in the most severely ill patients, to the widespread use of drugs that act on the central nervous system (CNS), with psychotherapy being an expensive luxury for a minority of patients. Samuel Barondes is well placed to review the psychopharmacol-ogy revolution and to offer predictions for the future, as he has worked through this period as a practising psychiatrist and as an active researcher who has made important contributions to the field.
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