Hepatitis A virus link to atopic disease

Jennifer J. McIntire; Sarah E. Umetsu; Claudia Macaubas; Elizabeth G. Hoyte; Cengiz Cinnioglu; Luigi L. Cavalli-Sforza; Gregory S. Barsh; Joachim F. Hallmayer; Peter A. Underhill; Neil J. Risch; Gordon J. Freeman; Rosemarie H. DeKruyff; Dale T. Umetsu

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Hepatitis A virus link to atopic disease

机译：甲型肝炎病毒与特应性疾病有关

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A topic diseases, including asthma, allergic rhinitis and atopic dermatitis, are caused by both environmental and genetic factors. Here we show that infection by hepatitis A virus (HAV) may protect individuals from atopy if they carry a particular variant of the gene that encodes TIM-1 (also known as HAVcr-1) ― the cell-surface receptor used by HAV to infect human cells. Exposure to HAV is associated with poor hygiene, large family size and attendance at day-care centres, all factors that are also inversely associated with atopy. Our discovery indicates that interaction between HAV and TIM-1 genotype may contribute to the aetiology of atopic diseases, and provides a mechanism to account for the hygiene hypothesis.

机译：包括哮喘，过敏性鼻炎和特应性皮炎在内的主题疾病是由环境和遗传因素共同引起的。在这里，我们表明，如果甲型肝炎病毒（HAV）携带编码TIM-1的基因的特定变体（也称为HAVcr-1），即甲型肝炎病毒用于感染的细胞表面受体，则甲型肝炎病毒的感染可以保护个体免受特应性疾病的侵袭。人类细胞。接触HAV与卫生条件差，家庭规模庞大以及在日托中心出勤有关，所有这些因素也与特应性成反比。我们的发现表明，HAV和TIM-1基因型之间的相互作用可能有助于特应性疾病的病因，并为解释卫生假说提供了一种机制。

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来源
《Nature》 |2003年第6958期|p.576|共1页
作者
Jennifer J. McIntire; Sarah E. Umetsu; Claudia Macaubas; Elizabeth G. Hoyte; Cengiz Cinnioglu; Luigi L. Cavalli-Sforza; Gregory S. Barsh; Joachim F. Hallmayer; Peter A. Underhill; Neil J. Risch; Gordon J. Freeman; Rosemarie H. DeKruyff; Dale T. Umetsu;
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作者单位

Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California 94305-5208, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Acute hepatitis A and acquired immunity to hepatitis A virus in hepatitis B virus (HBV) carriers and in HBV- or hepatitis C virus-related chronic liver diseases in Thailand. [J] . Pramoolsinsap C Journal of viral hepatitis. . 2000,第Suppla1期

机译：急性甲型肝炎，并在泰国的乙型肝炎病毒（HBV）携带者以及与HBV或C型肝炎病毒相关的慢性肝病中获得了对甲型肝炎病毒的免疫力。
2. Hepatitis B virus and microRNAs: Complex interactions affecting hepatitis B virus replication and hepatitis B virus-associated diseases [J] . Lamontagne Jason, Steel Laura F., Bouchard Michael J. World journal of gastroenterology : . 2015,第24期

机译：乙型肝炎病毒和microRNA：影响乙型肝炎病毒复制和乙型肝炎病毒相关疾病的复杂相互作用
3. IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease [J] . Amina A. Negash, Antonio Bertoletti, Brian Doehle, PLoS Pathogens . 2013,第4期

机译：肝巨噬细胞通过NLRP3炎性小体生产IL-1β将丙型肝炎病毒感染与肝炎和疾病联系起来
4. Increasing Evidence of Swine Viral Diseases Jumping the Species Barrier: Porcine Coronaviruses, Hepatitis E Virus and Torque Teno Virus [C] . Tanja Opriessnig Annual Meeting of the American College of Veterinary Pathologists . 2010

机译：越来越多的猪病毒疾病证据跳跃物种屏障：猪冠状病毒，乙型肝炎病毒和扭矩对象病毒
5. Virus specific CD8+ T cells protect against mouse hepatitis virus central nervous system disease. [D] . MacNamara, Katherine C. 2005

机译：病毒特异性CD8 + T细胞可预防小鼠肝炎病毒中枢神经系统疾病。
6. Enhanced Mucosal Immune Responses Induced by a Combined Candidate Mucosal Vaccine Based on Hepatitis A Virus and Hepatitis E Virus Structural Proteins Linked to Tuftsin [O] . Yan Gao, Qiudong Su, Yao Yi, -1

机译：由甲型肝炎病毒和戊型肝炎相关的戊型肝炎病毒结构蛋白联合候选候选粘膜疫苗诱导的增强的粘膜免疫反应
7. Hepatitis B virus and microRNAs: Complex interactions affecting hepatitis B virus replication and hepatitis B virus-associated diseases [O] . Jason Lamontagne 2015

机译：乙型肝炎病毒和MicroRNA：影响乙型肝炎病毒复制和乙型肝炎病毒相关疾病的复杂相互作用
8. Recommendations for Postexposure Interventions to Prevent Infection with Hepatitis B Virus, Hepatitis C Virus, or Human Immunodeficiency Virus, and Tetanus in Persons Wounded During Bombings and Similar Mass-Casualty Events-United States, 2008: Recommendations of the Centers for Disease Control (CDC). Morbidity and Mortality Weekly Report, Recommendation and Reports, Vol.57, No. RR-6 [R] . 2008

机译：关于暴露后干预以防止乙型肝炎病毒，丙型肝炎病毒或人类免疫缺陷病毒感染的建议，以及在爆炸和类似的大规模伤亡事件中受伤人员的破伤风 - 美国，2008年：疾病控制中心（CDC）的建议。发病率和死亡率每周报告，建议和报告，第57卷，第RR-6号

Hepatitis A virus link to atopic disease

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