An eye on organ development

Jonathan A. Epstein; Benjamin G. Neel

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An eye on organ development

机译：着眼于器官发育

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Studies in flies and mice have revealed a surprising way in which cells regulate gene activity, with consequences for our understanding of organ formation during development. The processes by which cells receive outside signals and transmit them into the nucleus have been so well scrutinized that one might think few surprises remain. But three papers in this issue show otherwise. During development, many of the signalling pathways that regulate organ formation are initiated by growth factors that bind to receptors on the cell surface. This triggers a cascade of events inside the cell that frequently involves the addition or removal of phosphate groups (phosphorylation or dephosphorylation, respectively) from cellular proteins. These proteins include those that regulate gene expression, such as transcription factors and their associated 'co-activators' and 'co-repressors'. Rayapureddi et al., Tootle el al. and Li et al. now report the intriguing finding that one type of transcription factor can itself dephosphorylate other proteins -- and that this function is crucial in various examples of organ formation. These results reveal a new way in which cells can fine-tune gene expression.

机译：对果蝇和小鼠的研究揭示了一种令人惊奇的细胞调节基因活性的方式，这对我们对发育过程中器官形成的理解产生了影响。细胞接受外部信号并将其传输至细胞核的过程受到了严格的审查，以至于人们可能认为仍然没有什么惊喜。但是，本期的三篇论文却相反。在发育过程中，许多调节器官形成的信号传导途径都是由与细胞表面受体结合的生长因子引发的。这触发了细胞内部的一系列事件，这些事件通常涉及从细胞蛋白质中添加或去除磷酸基团（分别为磷酸化或去磷酸化）。这些蛋白质包括调节基因表达的蛋白质，例如转录因子及其相关的“共激活因子”和“共抑制因子”。 Rayapureddi等，Tootle等。和李等。现在，我们报告了一个有趣的发现，即一种类型的转录因子本身可以使其他蛋白质脱磷酸化-并且这种功能在器官形成的各种例子中至关重要。这些结果揭示了细胞可以微调基因表达的新途径。

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来源
《Nature》 |2003年第6964期|p.238-239|共2页
作者
Jonathan A. Epstein; Benjamin G. Neel;
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作者单位

Cardiovascular Division, Department of Medicine, University of Pennsylvania, 954 BRB 11, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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An eye on organ development

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