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A neural circuit mechanism for medianosensory feedback control of ingestion

机译：用于摄取的中感觉反馈控制的神经回路机制

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摘要

Mechanosensory feedback from the digestive tract to the brain is critical for limiting excessive food and water intake, but the underlying gut-brain communication pathways and mechanisms remain poorly understood~(1-12). Here we show that, in mice, neurons in the parabrachial nucleus that express the prodynorphin gene (hereafter, PB~(Pdyn)neurons) monitor the intake of both fluids and solids, using mechanosensory signals that arise from the upper digestive tract. Most individual PB~(Pdyn)neurons are activated by ingestion as well as the stimulation of the mouth and stomach, which indicates the representation of integrated sensory signals across distinct parts of the digestive tract. PB~(Pdyn)neurons are anatomically connected to the digestive periphery via cranial and spinal pathways; we show that, among these pathways, the vagus nerve conveys stomach-distension signals to PB~(Pdyn)neurons. Upon receipt of these signals, these neurons produce aversive and sustained appetite-suppressing signals, which discourages the initiation of feeding and drinking (fully recapitulating the symptoms of gastric distension) in part via signalling to the paraventricular hypothalamus. By contrast, inhibiting the same population of PB~(Pdyn)neurons induces overconsumption only if a drive for ingestion exists, which confirms that these neurons mediate negative feedback signalling. Our findings reveal a neural mechanism that underlies the mechanosensory monitoring of ingestion and negative feedback control of intake behaviours upon distension of the digestive tract.
机译：从消化道到大脑的机械感官反馈对于限制过多的食物和水的摄入至关重要，但是潜在的肠脑沟通途径和机制仍然知之甚少（1-12）。在这里，我们表明，在小鼠中，表达前强啡肽基因的臂旁神经核中的神经元（以下称为PB〜（Pdyn）神经元）使用来自上消化道的机械感测信号来监测液体和固体的摄入。食入以及刺激口和胃会激活大多数PB〜（Pdyn）神经元，这表明了消化道不同部位的综合感觉信号表示。 PB〜（Pdyn）神经元在解剖学上通过颅和脊髓途径连接到消化系统。我们发现，在这些途径中，迷走神经将胃扩张信号传递给PB〜（Pdyn）神经元。收到这些信号后，这些神经元会产生厌恶和持续的食欲抑制信号，从而部分地通过向心室下丘脑发出信号来阻止开始进食和饮水（完全重现胃扩张的症状）。相比之下，仅当存在摄取驱动时，抑制相同的PB〜（Pdyn）神经元种群才会引起过度消费，这证实了这些神经元介导了负反馈信号。我们的发现揭示了一种神经机制，它是消化的机械感官监测和消化道扩张时摄入行为的负反馈控制的基础。

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  • 来源
    《Nature》 |2020年第7803期|376-380|共5页
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    Institute of Molecular Biology and Genetics Seoul National University|Program in Neuroscience Seoul National University;

    Institute of Molecular Biology and Genetics Seoul National University;

    Institute of Molecular Biology and Genetics Seoul National University|Department of Chemistry Seoul National University;

    Department of Pharmacy Seoul National University;

    Department of Medicine and Neuroscience Albert Einstein College of Medicine;

    Institute of Molecular Biology and Genetics Seoul National University|Program in Neuroscience Seoul National University|Department of Chemistry Seoul National University;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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