• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins
【24h】

Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins

机译：从马来西亚植物植物中分离SARS-COV-2相关冠状病毒

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The current outbreak of coronavirus disease-2019 (COVID-19) poses unprecedented challenges to global health(1). The new coronavirus responsible for this outbreak-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-shares high sequence identity to SARS-CoV and a bat coronavirus, RaTG13(2). Although bats may be the reservoir host for a variety of coronaviruses(3,4), it remains unknown whether SARS-CoV-2 has additional host species. Here we show that a coronavirus, which we name pangolin-CoV, isolated from a Malayan pangolin has 100%, 98.6%, 97.8% and 90.7% amino acid identity with SARS-CoV-2 in the E, M, N and S proteins, respectively. In particular, the receptor-binding domain of the S protein of pangolin-CoV is almost identical to that of SARS-CoV-2, with one difference in a noncritical amino acid. Our comparative genomic analysis suggests that SARS-CoV-2 may have originated in the recombination of a virus similar to pangolin-CoV with one similar to RaTG13. Pangolin-CoV was detected in 17 out of the 25 Malayan pangolins that we analysed. Infected pangolins showed clinical signs and histological changes, and circulating antibodies against pangolin-CoV reacted with the S protein of SARS-CoV-2. The isolation of a coronavirus from pangolins that is closely related to SARS-CoV-2 suggests that these animals have the potential to act as an intermediate host of SARS-CoV-2. This newly identified coronavirus from pangolins-the most-trafficked mammal in the illegal wildlife trade-could represent a future threat to public health if wildlife trade is not effectively controlled.
机译：目前的冠状病毒病 - 2019年（Covid-19）对全球健康（1）造成了前所未有的挑战。负责这种爆发严重的急性呼吸综合征冠状病毒2（SARS-COV-2）的新冠状病毒 - SARS-COV和蝙蝠冠状病毒，RATG13（2）的高序列同一性。虽然蝙蝠可能是各种冠状虫病毒（3,4）的储层宿主，但仍然未知SARS-COV-2是否具有额外的宿主物种。在这里，我们展示了冠状病毒，其中从马来亚植物中分离出来的鹅唑啉-CoV，在e，m，n和s蛋白中的SARS-COV-2具有100％，98.6％，97.8％和90.7％氨基酸同一性， 分别。特别地，Pangolin-CoV的S蛋白的受体结合结构域与SARS-COV-2的蛋白质结合结构域几乎相同，非临界氨基酸的一个差异。我们的比较基因组分析表明，SARS-COV-2可能已经起源于类似于Pangolin-CoV的病毒的重组，其中一个类似于RATG13。在我们分析的25名马来山山谷中，在17中检测到Pangolin-CoV。受感染的植物蛋白显示临床症状和组织学变化，并对Pangolin-CoV的循环抗体与SARS-COV-2的S蛋白反应。从与SARS-COV-2密切相关的Pangolins的分离冠状病毒表明这些动物具有充当SARS-COV-2的中间宿主的潜力。来自植物素的新鉴定的冠状病毒 - 非法野生动物贸易中最贩运的哺乳动物 - 如果没有有效控制野生动物贸易，可能代表对公共卫生的未来威胁。

著录项

  • 来源
    《Nature》 |2020年第7815期|286-289|共4页
  • 作者

    Xiao Kangpeng; Zhai Junqiong; Feng Yaoyu; Zhou Niu; Zhang Xu; Zou Jie-Jian; Li Na; Guo Yaqiong; Li Xiaobing; Shen Xuejuan; Zhang Zhipeng; Shu Fanfan; Huang Wanyi; Li Yu; Zhang Ziding; Chen Rui-Ai; Wu Ya-Jiang; Peng Shi-Ming; Huang Mian; Xie Wei-Jun; Cai Qin-Hui; Hou Fang-Hui; Chen Wu; Xiao Lihua; Shen Yongyi;

  • 作者单位

    South China Agr Univ Coll Vet Med Ctr Emerging & Zoonot Dis Guangzhou Peoples R China|Guangdong Lab Lingnan Modern Agr Guangzhou Peoples R China;

    Guangzhou Zoo Guangzhou Peoples R China|Guangzhou Wildlife Res Ctr Guangzhou Peoples R China;

    South China Agr Univ Coll Vet Med Ctr Emerging & Zoonot Dis Guangzhou Peoples R China|Guangdong Lab Lingnan Modern Agr Guangzhou Peoples R China;

    Guangzhou Zoo Guangzhou Peoples R China|Guangzhou Wildlife Res Ctr Guangzhou Peoples R China;

    South China Agr Univ Coll Vet Med Ctr Emerging & Zoonot Dis Guangzhou Peoples R China|Guangdong Lab Lingnan Modern Agr Guangzhou Peoples R China;

    Guangdong Prov Wildlife Rescue Ctr Guangzhou Peoples R China;

    South China Agr Univ Coll Vet Med Ctr Emerging & Zoonot Dis Guangzhou Peoples R China|Guangdong Lab Lingnan Modern Agr Guangzhou Peoples R China;

    South China Agr Univ Coll Vet Med Ctr Emerging & Zoonot Dis Guangzhou Peoples R China|Guangdong Lab Lingnan Modern Agr Guangzhou Peoples R China;

    South China Agr Univ Coll Vet Med Ctr Emerging & Zoonot Dis Guangzhou Peoples R China;

    South China Agr Univ Coll Vet Med Ctr Emerging & Zoonot Dis Guangzhou Peoples R China;

    South China Agr Univ Coll Vet Med Ctr Emerging & Zoonot Dis Guangzhou Peoples R China;

    South China Agr Univ Coll Vet Med Ctr Emerging & Zoonot Dis Guangzhou Peoples R China|Guangdong Lab Lingnan Modern Agr Guangzhou Peoples R China;

    South China Agr Univ Coll Vet Med Ctr Emerging & Zoonot Dis Guangzhou Peoples R China|Guangdong Lab Lingnan Modern Agr Guangzhou Peoples R China;

    China Agr Univ Coll Biol Sci State Key Lab Agrobiotechnol Beijing Peoples R China;

    China Agr Univ Coll Biol Sci State Key Lab Agrobiotechnol Beijing Peoples R China;

    South China Agr Univ Coll Vet Med Ctr Emerging & Zoonot Dis Guangzhou Peoples R China|Zhaoqing Branch Ctr Guangdong Lab Lingnan Modern Agr Sci & Technol Zhaoqing Peoples R China;

    Guangzhou Zoo Guangzhou Peoples R China|Guangzhou Wildlife Res Ctr Guangzhou Peoples R China;

    Guangzhou Zoo Guangzhou Peoples R China|Guangzhou Wildlife Res Ctr Guangzhou Peoples R China;

    Guangzhou Zoo Guangzhou Peoples R China|Guangzhou Wildlife Res Ctr Guangzhou Peoples R China;

    Guangzhou Zoo Guangzhou Peoples R China|Guangzhou Wildlife Res Ctr Guangzhou Peoples R China;

    Guangzhou Zoo Guangzhou Peoples R China|Guangzhou Wildlife Res Ctr Guangzhou Peoples R China;

    Guangdong Prov Wildlife Rescue Ctr Guangzhou Peoples R China;

    Guangzhou Zoo Guangzhou Peoples R China|Guangzhou Wildlife Res Ctr Guangzhou Peoples R China;

    South China Agr Univ Coll Vet Med Ctr Emerging & Zoonot Dis Guangzhou Peoples R China|Guangdong Lab Lingnan Modern Agr Guangzhou Peoples R China;

    South China Agr Univ Coll Vet Med Ctr Emerging & Zoonot Dis Guangzhou Peoples R China|Guangdong Lab Lingnan Modern Agr Guangzhou Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号