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Dopamine-based mechanism for transient forgetting

机译：基于多巴胺的瞬态遗忘机制

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摘要

Active forgetting is an essential component of the memory management system of the brain(1). Forgetting can be permanent, in which prior memory is lost completely, or transient, in which memory exists in a temporary state of impaired retrieval. Temporary blocks on memory seem to be universal, and can disrupt an individual's plans, social interactions and ability to make rapid, flexible and appropriate choices. However, the neurobiological mechanisms that cause transient forgetting are unknown. Here we identify a single dopamine neuron in Drosophila that mediates the memory suppression that results in transient forgetting. Artificially activating this neuron did not abolish the expression of long-term memory. Instead, it briefly suppressed memory retrieval, with the memory becoming accessible again over time. The dopamine neuron modulates memory retrieval by stimulating a unique dopamine receptor that is expressed in a restricted physical compartment of the axons of mushroom body neurons. This mechanism for transient forgetting is triggered by the presentation of interfering stimuli immediately before retrieval.
机译：主动忘记是大脑的内存管理系统的重要组成部分（1）。遗忘可以是永久性的，其中先前的内存完全丢失或瞬态，其中存储器存在于检索受损的临时状态。 Temporary blocks on memory seem to be universal, and can disrupt an individual's plans, social interactions and ability to make rapid, flexible and appropriate choices.然而，导致瞬态遗忘的神经生物学机制是未知的。在这里，我们鉴定果蝇中的单一多巴胺神经元，介于介导的记忆抑制，导致瞬态遗忘。人工激活这种神经元并未取消长期记忆的表达。相反，它短暂地抑制了内存检索，内存随时间再次访问。多巴胺神经元通过刺激在蘑菇体神经元的轴突中的限制物理隔室中表达的独特多巴胺受体来调节内存检索。这种瞬态遗忘机制是通过在检索前立即干扰刺激的呈现来引发的。

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  • 来源
    《Nature》 |2021年第7850期|426-430|共5页
  • 作者

    Sabandal John Martin; Berry Jacob A.; Davis Ronald L.;

  • 作者单位

    Scripps Res Inst Florida Dept Neurosci Jupiter FL 33458 USA;

    Scripps Res Inst Florida Dept Neurosci Jupiter FL 33458 USA;

    Scripps Res Inst Florida Dept Neurosci Jupiter FL 33458 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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