• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >A clinically applicable integrative molecular classification of meningiomas
【24h】

A clinically applicable integrative molecular classification of meningiomas

机译：脑膜瘤的临床适用的整合分子分类

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Meningiomas are the most common primary intracranial tumour in adults(1). Patients with symptoms are generally treated with surgery as there are no effective medical therapies. The World Health Organization histopathological grade of the tumour and the extent of resection at surgery (Simpson grade) are associated with the recurrence of disease; however, they do not accurately reflect the clinical behaviour of all meningiomas(2). Molecular classifications of meningioma that reliably reflect tumour behaviour and inform on therapies are required. Here we introduce four consensus molecular groups of meningioma by combining DNA somatic copy-number aberrations, DNA somatic point mutations, DNA methylation and messenger RNA abundance in a unified analysis. These molecular groups more accurately predicted clinical outcomes compared with existing classification schemes. Each molecular group showed distinctive and prototypical biology (immunogenic, benign NF2 wild-type, hypermetabolic and proliferative) that informed therapeutic options. Proteogenomic characterization reinforced the robustness of the newly defined molecular groups and uncovered highly abundant and group-specific protein targets that we validated using immunohistochemistry. Single-cell RNA sequencing revealed inter-individual variations in meningioma as well as variations in intrinsic expression programs in neoplastic cells that mirrored the biology of the molecular groups identified.
机译：脑膜瘤是成人中最常见的主要颅内肿瘤（1）。症状患者通常用手术治疗，因为没有有效的医疗疗法。世界卫生组织的肿瘤组织病理学等级以及手术切除程度（辛普森等级）与疾病的复发有关;但是，它们没有准确反映所有脑膜瘤的临床行为（2）。可靠地反映肿瘤行为的脑膜瘤的分子分类，并提供通知疗法。在这里，我们通过在统一分析中结合DNA体细胞拷贝数，DNA躯体点突变，DNA甲基化和信使RNA丰度来介绍四种共识的脑膜瘤。与现有的分类方案相比，这些分子基团更准确地预测临床结果。每个分子基团都显示出明显的和原型的生物学（免疫原性，良性NF2野生型，超代谢和增殖），可通知治疗方案。蛋白质表征增强了新定义的分子基团的稳健性，并发现了我们使用免疫组织化学验证的高度丰富和群体特异性蛋白质靶标。单细胞RNA测序显示脑膜瘤间的个体间变化以及肿瘤细胞中的内在表达程序中的变化，反映了所鉴定的分子基团的生物学。

著录项

  • 来源
    《Nature》 |2021年第7874期|119-125|共7页
  • 作者

    Nassiri Farshad; Liu Jeff; Patil Vikas; Mamatjan Yasin; Wang Justin Z.; Hugh-White Rupert; Macklin Andrew M.; Khan Shahbaz; Singh Olivia; Karimi Shirin; Corona Rosario I.; Liu Lydia Y.; Chen Caroline Y.; Chakravarthy Ankur; Wei Qingxia; Mehani Bharati; Suppiah Suganth; Gao Andrew; Workewych Adriana M.; Tabatabai Ghazaleh; Boutros Paul C.; Bader Gary D.; de Carvalho Daniel D.; Kislinger Thomas; Aldape Kenneth; Zadeh Gelareh;

  • 作者单位

    Univ Hlth Network Princess Margaret Canc Ctr MacFeeters Hamilton Neurooncol Program Toronto ON Canada|Univ Toronto Toronto ON Canada|Univ Toronto Div Neurosurg Dept Surg Toronto ON Canada|Int Consortium Meningiomas Toronto ON Canada;

    Univ Hlth Network Princess Margaret Canc Ctr MacFeeters Hamilton Neurooncol Program Toronto ON Canada|Univ Toronto Toronto ON Canada|Int Consortium Meningiomas Toronto ON Canada;

    Univ Hlth Network Princess Margaret Canc Ctr MacFeeters Hamilton Neurooncol Program Toronto ON Canada|Univ Toronto Toronto ON Canada|Int Consortium Meningiomas Toronto ON Canada;

    Univ Hlth Network Princess Margaret Canc Ctr MacFeeters Hamilton Neurooncol Program Toronto ON Canada|Univ Toronto Toronto ON Canada|Int Consortium Meningiomas Toronto ON Canada;

    Univ Hlth Network Princess Margaret Canc Ctr MacFeeters Hamilton Neurooncol Program Toronto ON Canada|Univ Toronto Toronto ON Canada|Univ Toronto Div Neurosurg Dept Surg Toronto ON Canada|Int Consortium Meningiomas Toronto ON Canada;

    Univ Calif Los Angeles David Geffen Sch Med Jonsson Comprehens Canc Ctr Los Angeles CA 90095 USA;

    Univ Hlth Network Princess Margaret Canc Ctr Toronto ON Canada;

    Univ Hlth Network Princess Margaret Canc Ctr Toronto ON Canada;

    Univ Hlth Network Princess Margaret Canc Ctr MacFeeters Hamilton Neurooncol Program Toronto ON Canada;

    Univ Hlth Network Princess Margaret Canc Ctr MacFeeters Hamilton Neurooncol Program Toronto ON Canada;

    Univ Calif Los Angeles David Geffen Sch Med Jonsson Comprehens Canc Ctr Los Angeles CA 90095 USA;

    Univ Calif Los Angeles David Geffen Sch Med Jonsson Comprehens Canc Ctr Los Angeles CA 90095 USA|Univ Toronto Dept Med Biophys Toronto ON Canada;

    Univ Calif Los Angeles David Geffen Sch Med Jonsson Comprehens Canc Ctr Los Angeles CA 90095 USA;

    Univ Hlth Network Princess Margaret Canc Ctr Toronto ON Canada;

    Univ Hlth Network Princess Margaret Canc Ctr MacFeeters Hamilton Neurooncol Program Toronto ON Canada;

    NCI Pathol Lab Ctr Canc Res Bldg 10 Bethesda MD 20892 USA;

    Univ Hlth Network Princess Margaret Canc Ctr MacFeeters Hamilton Neurooncol Program Toronto ON Canada|Univ Toronto Toronto ON Canada|Univ Toronto Div Neurosurg Dept Surg Toronto ON Canada|Int Consortium Meningiomas Toronto ON Canada;

    Univ Hlth Network Lab Med Program Toronto ON Canada;

    Univ Hlth Network Princess Margaret Canc Ctr MacFeeters Hamilton Neurooncol Program Toronto ON Canada;

    Int Consortium Meningiomas Toronto ON Canada|Univ Hosp Tubingen Hertie Inst Clin Brain Res Dept Neurol & Interdisciplinary Neurooncol Ctr Neurooncol Comprehens Canc Ctr Tubingen Germany;

    Int Consortium Meningiomas Toronto ON Canada|Univ Calif Los Angeles David Geffen Sch Med Jonsson Comprehens Canc Ctr Los Angeles CA 90095 USA|Univ Calif Los Angeles Dept Human Genet Los Angeles CA USA;

    Univ Toronto Donnelly Ctr Toronto ON Canada|Univ Toronto Dept Mol Genet Toronto ON Canada|Univ Toronto Dept Comp Sci Toronto ON Canada|Mt Sinai Hosp Lunenfeld Tanenbaum Res Inst Toronto ON Canada;

    Univ Hlth Network Princess Margaret Canc Ctr Toronto ON Canada|Univ Toronto Dept Med Biophys Toronto ON Canada;

    Int Consortium Meningiomas Toronto ON Canada|Univ Hlth Network Princess Margaret Canc Ctr Toronto ON Canada|Univ Toronto Dept Med Biophys Toronto ON Canada;

    Univ Hlth Network Princess Margaret Canc Ctr MacFeeters Hamilton Neurooncol Program Toronto ON Canada|Int Consortium Meningiomas Toronto ON Canada|NCI Pathol Lab Ctr Canc Res Bldg 10 Bethesda MD 20892 USA;

    Univ Hlth Network Princess Margaret Canc Ctr MacFeeters Hamilton Neurooncol Program Toronto ON Canada|Univ Toronto Toronto ON Canada|Univ Toronto Div Neurosurg Dept Surg Toronto ON Canada|Int Consortium Meningiomas Toronto ON Canada|Univ Hlth Network Princess Margaret Canc Ctr Toronto ON Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号