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An endothelial receptor for oxidized low-density lipoprotein

机译:氧化型低密度脂蛋白的内皮受体

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Endothelial dysfunction or activation elicited by oxidatively modified low-density lipoprotein (Ox-LDL) has been implicated in the pathogenesis of atherosclerosis, characterized by intimal thickening and lipid deposition in the arteries. Ox-LDL and its lipid constituents impair endothelial production of nitric oxide, and induce the endothelial expression of leukocyte adhesion molecules and smooth-muscle growth factors, which may be involved in atherogenesis. Vascular endothelial cells in culture and in vivo internalize and degrade Ox-LDL through a putative receptor-mediated pathway that does not involve macrophage scavenger receptors. Here we report the molecular cloning, using expression cloning strategy, of an Ox-LDL receptor from vascular endothelial cells. The cloned receptor is a membrane protein that belongs structurally to the C-type lectin family, and is expressed in vivo in vascular endothelium and vascular-rich organs.
机译:由氧化修饰的低密度脂蛋白(Ox-LDL)引起的内皮功能障碍或激活与动脉粥样硬化的发病机制有关,其特征在于动脉内膜增厚和脂质沉积。 Ox-LDL及其脂质成分损害一氧化氮的内皮生成,并诱导白细胞粘附分子和平滑肌生长因子的内皮表达,这可能参与动脉粥样硬化的形成。培养和体内的血管内皮细胞通过推定的受体介导的途径(不涉及巨噬细胞清除剂受体)内化并降解Ox-LDL。在这里,我们报告了使用表达克隆策略从血管内皮细胞克隆Ox-LDL受体的分子。克隆的受体是一种膜蛋白,在结构上属于C型凝集素家族,在体内表达于血管内皮和富含血管的器官中。

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