Phylogenesis of prion protein

David C. Krakauer; Mark Pagel; T. R. E. Southwood; Paolo M. de A. Zanotto

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Phylogenesis of prion protein

机译：ion病毒蛋白的系统发育

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We have reconstructed the phy-logeny for various mammal species based on the sequence of the prion protein gene. By tracing the pattern of amino-acid substitutions through the phylogeny, we have identified two pairs of derived substitutions uniquely shared by cattle (Bos taunts) and the hominoids. Although we have no specific explanation for these events, a phylogenetic analysis can help to indicate their significance. Two factors make the result compelling: the probability that it occurred by chance is estimated to be less than 1.2x10~(-4); and the substitutions, although of a conservative nature, occur in a region of the gene postulated to be involved in the acquisition of prion diseases.

机译：我们已经基于pr病毒蛋白基因的序列重建了各种哺乳动物的phy-logeny。通过追溯系统发育中氨基酸取代的模式，我们确定了两对被牛（Bos嘲讽）和类人动物共有的衍生取代。尽管我们没有这些事件的具体解释，但系统发育分析可以帮助表明它们的重要性。有两个因素使结果令人信服：估计偶然发生的概率小于1.2x10〜（-4）；取代虽然具有保守性，但发生在假定与the病毒疾病的发生有关的基因区域。

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《Nature》 |1996年第6576期|p.675|共1页
作者
David C. Krakauer; Mark Pagel; T. R. E. Southwood; Paolo M. de A. Zanotto;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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机译：动态表达的ion病毒样蛋白在秀丽隐杆线虫的咽部形成角质层动态表达的ion病毒样蛋白在秀丽隐杆线虫的咽部中形成角质层
2. Association of prion protein genotype and scrapie prion protein type with cellular prion protein charge isoform profiles in cerebrospinal fluid of humans with sporadic or familial prion diseases [J] . SchmitzM., LüllmannK., ZafarS., Neurobiology of Aging: Experimental and Clinical Research . 2014,第5期

机译：散发性或家族性病毒病患者脑脊液中病毒蛋白基因型和瘙痒病pr病毒蛋白类型与细胞病毒蛋白电荷同工型的关系
3. Metabolism of minor isoforms of prion proteins: Cytosolic prion protein and transmembrane prion protein [J] . Zhiqi Song, Deming Zhao, Lifeng Yang Neural regeneration research . 2013,第30期

机译：小朊病毒蛋白的轻微同种型的新陈代谢：胞质朊病毒蛋白和跨膜朊病毒蛋白
4. Inter-subunit contacts in prion oligomers studied by crosslinking of 15N-metabolically labeled prion proteins [C] . Jason J. Serpa, Evgeniy V. Petrotchenko, David S. Wishart, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：通过交联15N-代谢标记的朊病毒蛋白研究的朊病毒间寡聚蛋白的亚基偶极聚合物
5. Neurobehavioral impairments of prion protein deficient mice in olfactory tasks: Towards a functional understanding of the cellular prion protein PrP(C). [D] . Le Pichon, Claire. 2007

机译：嗅觉任务中的ion病毒蛋白缺陷小鼠的神经行为损害：对细胞病毒蛋白PrP（C）的功能性理解。
6. Conservation and Variability of Synaptonemal Complex Proteins in Phylogenesis of Eukaryotes [O] . Tatiana M. Grishaeva, Yuri F. Bogdanov 2014

机译：突触复合蛋白在真核生物发生中的保守性和变异性
7. Mitochondrial uncoupling proteins and phylogenesis – UCP4 as the ancestral uncoupling protein [O] . Hanák Petr, Ježek Petr 2001

机译：线粒体解偶联蛋白和系统发育– UCP4作为祖先解偶联蛋白

Phylogenesis of prion protein

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