'Distorted' RNA helix recognition

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'Distorted' RNA helix recognition

机译：“扭曲”的RNA螺旋识别

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Ibba and Soll have proposed a resolution for an apparent controversy over the basis for recognition of a critical G-U wobble base pair in an RNA helix. We wish to point out that their proposal is not supported by extensive published literature and that more plausible explanations are available. The controversy' has surrounded the question of how the G-U pair at the third position in the acceptor helix of alanine transfer (t)RNAs is recognized by its cognate synthetase. In vitro experiments with a multitude of natural bases and nonnatural base analogues narrowed down the functional site to the free 2-amino group contributed by G of the G-U pair. (Unlike the G-C Watson-Crick pair, the G-U wobble pair places the 2-amino group of G in the RNA minor groove as an unpaired functional group.) These experiments included a demonstration that simple removal of the 2-amino group (using an I-U pair), with no other change, was sufficient to abolish aminoacylation with alanine. Restoration of the free 2-amino group by substitution of a non-natural base pair (2-amino adenosine paired with isocytidine) restored aminoacvlation with alanine.

机译：Ibba和Soll提出了一个解决方案，该方案在识别RNA螺旋中关键的G-U摆动碱基对的基础上存在明显争议。我们希望指出，他们的建议没有得到广泛发表的文献的支持，并且有更多可能的解释。争论围绕着一个问题，即丙氨酸转移（t）RNA受体螺旋的第三位G-U对如何被其同源合成酶识别。用多种天然碱基和非天然碱基类似物进行的体外实验将功能位点缩小到由G-U对的G贡献的游离2-氨基。（与GC Watson-Crick对不同，GU摆动对将G的2个氨基保留在RNA小沟中作为未配对的官能团。）这些实验包括一个简单的去除2个氨基的实验（使用IU对），没有其他变化，足以消除丙氨酸的氨基酰化作用。通过取代非天然碱基对（2-氨基腺苷与异胞苷配对）来恢复游离的2-氨基基团可以恢复丙氨酸的氨基酰基化作用。

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《Nature》 |1996年第6608期|p.422|共1页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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'Distorted' RNA helix recognition

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