CD22 regulates thymus-independent responses and the lifespan of B cells.

Otipoby KL; Andersson KB; Draves KE; Klaus SJ; Farr AG; Kerner JD; Perlmutter RM; Law CL; Clark EA

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CD22 regulates thymus-independent responses and the lifespan of B cells.

机译：CD22调节胸腺非依赖性反应和B细胞的寿命。

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The B-lymphocyte-restricted glycoprotein CD22 is expressed on mature IgM+IgD+ B cells, and is capable of binding to ligands on T and B cells. CD22 can interact with both the B-cell antigen receptor (BCR) complex and signalling molecules, including the protein tyrosine phosphatase SHP1 (PTP1C, SHP), a putative negative regulator of BCR signalling. Thus CD22 may facilitate interactions with lymphocytes and regulate the threshold of BCR signalling. To define the in vivo function of CD22, we generated CD22-deficient mice. Here we show that CD22 is required for normal antibody responses to thymus-independent antigens and regulates the lifespan of mature B cells.

机译：B淋巴细胞限制性糖蛋白CD22在成熟的IgM + IgD + B细胞上表达，并能够与T和B细胞上的配体结合。 CD22可以与B细胞抗原受体（BCR）复合体和信号分子相互作用，包括酪氨酸磷酸酶SHP1蛋白（PTP1C，SHP），一种BCR信号的负调节剂。因此，CD22可促进与淋巴细胞的相互作用并调节BCR信号转导的阈值。为了定义CD22的体内功能，我们产生了CD22缺陷的小鼠。在这里，我们显示CD22是正常的对胸腺非依赖性抗原的抗体应答所必需的，并调节成熟B细胞的寿命。

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来源
《Nature》 |1996年第6610期|P.634-637|共4页
作者
Otipoby KL; Andersson KB; Draves KE; Klaus SJ; Farr AG; Kerner JD; Perlmutter RM; Law CL; Clark EA;
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作者单位

Department of Immunology, University of Washington Medical Center, Seattle 98195, USA.;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
Antigens; CD; Antigens; Differentiation; B-Lymphocyte; B-Lymphocytes; CD22-antigen; 抗原; CD; 抗原; 分化; B淋巴细胞; B淋巴细胞;

机译：Antigens;CD;Antigens;Differentiation;B-Lymphocyte;B-Lymphocytes;CD22-antigen;抗原;CD;抗原;分化;B淋巴细胞;B淋巴细胞;

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1. CD22 Regulates Adaptive and Innate Immune Responses of B Cells. [J] . Kawasaki N, Rademacher C, Paulson JC Journal of innate immunity . 2011,第4期

机译：CD22调节B细胞的适应性免疫反应和先天免疫反应。
2. Adapter molecule Grb2-associated binder 1 is specifically expressed in marginal zone B cells and negatively regulates thymus-independent antigen-2 responses. [J] . Itoh S, Itoh M, Nishida K, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2002,第10期

机译：衔接子分子与Grb2相关的黏合剂1在边缘区B细胞中特异性表达，并负调节胸腺非依赖性抗原2反应。
3. Adapter Molecule Grb2-Associated Binder 1 Is Specifically Expressed in Marginal Zone B Cells and Negatively Regulates Thymus-Independent Antigen-2 Responses [J] . Shousaku Itoh, Motoyuki Itoh, Keigo Nishida, The journal of immunology . 2002,第10期

机译：适配器分子Grb2相关联的活页夹1在边缘区B细胞中特别表达，并负调节胸腺独立抗原2响应。
4. A T1D-associated lncRNA modulates the type I interferon signaling and the antiviral response in pancreatic beta cells. [C] . Itziar Gonzalez-Moro, Izortze Santin IEEE International Conference on Bioinformatics and Biomedicine . 2020

机译：T1D相关的LNCRNA调节I型干扰素信号传导和胰腺β细胞中的抗病毒反应。
5. Novel role of heat shock protein (HSP) 90 in regulating ATR-CHK1 DNA damage response pathway in cancer cells. [D] . Ha, Kyungsoo. 2011

机译：热休克蛋白（HSP）90在调节癌细胞中ATR-CHK1 DNA损伤反应途径中的新作用。
6. CD22 Regulates Adaptive and Innate Immune Responses of B Cells [O] . Norihito Kawasaki, Christoph Rademacher, James C. Paulson 2011

机译：CD22调节B细胞的适应性和先天性免疫反应。
7. Adapter Molecule Grb2-Associated Binder 1 Is Specifically Expressed in Marginal Zone B Cells and Negatively Regulates Thymus-Independent Antigen-2 Responses [O] . Shousaku Itoh, Motoyuki Itoh, Keigo Nishida, 2002

机译：适配器分子GRB2相关粘合剂1在边缘区B细胞中特异性地表达，并对胸腺无关的抗原-2响应进行负调节

CD22 regulates thymus-independent responses and the lifespan of B cells.

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