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首页> 外文期刊>Neurological Sciences >Minocycline with aspirin: a therapeutic approach in the treatment of diabetic neuropathy
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Minocycline with aspirin: a therapeutic approach in the treatment of diabetic neuropathy

机译：米诺环素联合阿司匹林：治疗糖尿病神经病变的治疗方法

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摘要

Enhanced production of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in diabetes leads to degradation of extracellular matrix in blood vessels and leads to complications of diabetes. In the present study, we have targeted MMP-2 and MMP-9 overactivation in diabetic neuropathy using a known MMP-2 and MMP-9 inhibitor, minocycline, with a non-selective COX inhibitor, aspirin. Streptozotocin-induced diabetic neuropathy was carried out in male Wistar rats and monitored by measuring the sensory nerve conduction velocity (SNCV), motor nerve conduction velocity (MNCV), tail flick latency and hot plate latency. Three weeks of treatment with a combination of minocycline and aspirin showed significant improvement in SNCV, MNCV, hot plate latency and tail flick latency when compared with diabetic control. The results of the present study suggest that MMP-2 and MMP-9 inhibition in the presence of COX inhibitor prevents the development of experimental diabetic neuropathy in rats and can be a potential approach for the treatment.
机译：糖尿病中基质金属蛋白酶2（MMP-2）和基质金属蛋白酶9（MMP-9）产量的增加导致血管中细胞外基质的降解，并导致糖尿病并发症。在本研究中，我们使用已知的MMP-2和MMP-9抑制剂美诺环素与非选择性COX抑制剂阿司匹林来针对糖尿病性神经病变中的MMP-2和MMP-9过度活化。在雄性Wistar大鼠中进行链脲佐菌素诱导的糖尿病性神经病变，并通过测量感觉神经传导速度（SNCV），运动神经传导速度（MNCV），甩尾潜伏期和热板潜伏期进行监测。与糖尿病对照组相比，米诺环素和阿司匹林联合治疗三周显示SNCV，MNCV，热板潜伏期和甩尾潜伏期显着改善。本研究的结果表明，在存在COX抑制剂的情况下抑制MMP-2和MMP-9可以防止大鼠实验性糖尿病性神经病的发展，并且可能是一种潜在的治疗方法。

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