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首页> 外文期刊>Pediatric Cardiology >Late Aortic Root Dilatation in Tetralogy of Fallot may be Prevented by Early Repair in Infancy
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Late Aortic Root Dilatation in Tetralogy of Fallot may be Prevented by Early Repair in Infancy

机译：婴儿早期修复可预防法洛四联症的晚期主动脉根部扩张

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摘要

The objectives of this study were to examine the relative contributions of development and hemodynamics in aortic root dilatation of tetralogy of Fallot, to assess the impact of systemic to pulmonary artery shunt on aortic annular size, and to seek any relationship between the timing of corrective surgery and subsequent aortic root size. We performed a retrospective analytical study at a tertiary referral center of M-mode and two-dimensionol aortic root measurements in children with tetralogy of Fallot prior to any surgical or palliative intervention, after insertion of a surgical shunt, and on intermediate and long-term follow-up post-repair. The main outcome measures were aortic root diameter prior to correction, after palliative shunt insertion, and after definitive repair. The study found that the aortic root is enlarged in unrepaired tetralogy of Fallot irrespective of age, increased in the first 3–6 months after palliative shunt surgery, and persisted into adulthood in those repaired after 1 year of age. Age-corrected aortic root dimensions normalized by midchildhood in those who were repaired in infancy. Preexisting aortic root dilatation normalizes by 7 years of age in patients with tetralogy of Fallot who have been repaired in infancy, whereas it persists into adulthood in the group repaired postinfancy.
机译：这项研究的目的是检查法洛四联症的主动脉根扩张中发育和血流动力学的相对贡献，评估全身性至肺动脉分流对主动脉环尺寸的影响，并寻求矫正手术时机之间的任何关系以及随后的主动脉根大小。在进行任何外科或姑息性干预，插入手术分流器之后以及中期和长期治疗之前，我们对患有法洛四联症的儿童在M型和二维主动脉根部三级转诊中心进行了回顾性分析研究修复后的跟进。主要结局指标是矫正前，姑息分流术插入后和确定性修复后的主动脉根直径。研究发现，不论年龄大小，在未修复的法洛四联症中，主动脉根部均增大，在姑息分流手术后的前3–6个月内增大，并在成年后的1年内持续到成年。在婴儿期得到修复的患者中，年龄校正的年龄校正了的主动脉根部尺寸。在婴儿期已修复的法洛四联症患者中，已存在的主动脉根部扩张可在7岁时恢复正常，而在婴儿期已修复的组中，这种情况一直持续到成年。

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