Monitoring Effects of Excipients, Formulation Parameters and Mutations on the High Order Structure of Filgrastim by NMR

Yves Aubin; Derek J. Hodgson; William B. Thach; Geneviève Gingras; Simon Sauvé

首页> 外文期刊>Pharmaceutical Research >Monitoring Effects of Excipients, Formulation Parameters and Mutations on the High Order Structure of Filgrastim by NMR

【24h】

Monitoring Effects of Excipients, Formulation Parameters and Mutations on the High Order Structure of Filgrastim by NMR

机译：NMR监测辅料，配方参数和突变对非格司亭高阶结构的影响

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Purpose Filgrastim is the generic name for recombinant methionyl human granulocyte colony-stimulating factor (r-metHuG-CSF). It is marketed under the brand name Neupogen® by Amgen. Since this product has lost patent protection, many biosimilar versions have been approved or are in the process of filing for market authorization throughout the world. Here we show that NMR spectroscopy can be used to assess the three-dimensional structure of the active ingredient in the formulated approved product Neupogen®.

机译：目的Filgrastim是重组蛋氨酸人粒细胞集落刺激因子（r-metHuG-CSF）的总称。它由Amgen以Neupogen®品牌销售。由于该产品失去了专利保护，因此许多生物仿制药均已获批准或正在申请全球市场许可。在这里，我们表明，NMR光谱可用于评估已配制的批准产品Neupogen®中活性成分的三维结构。

著录项

来源
《Pharmaceutical Research》 |2015年第10期|3365-3375|共11页
作者
Yves Aubin; Derek J. Hodgson; William B. Thach; Geneviève Gingras; Simon Sauvé;
展开▼
作者单位

Centre for Biologics Evaluation Biologics and Genetic Therapies Directorate Health Canada">(1);

Centre for Biologics Evaluation Biologics and Genetic Therapies Directorate Health Canada">(1);

Centre for Biologics Evaluation Biologics and Genetic Therapies Directorate Health Canada">(1);

Centre for Biologics Evaluation Biologics and Genetic Therapies Directorate Health Canada">(1);

Centre for Biologics Evaluation Biologics and Genetic Therapies Directorate Health Canada">(1);

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. Monitoring Effects of Excipients, Formulation Parameters and Mutations on the High Order Structure of Filgrastim by NMR [J] . Aubin Yves, Hodgson Derek J., Thach William B., Pharmaceutical research . 2015,第10期

机译：NMR监测辅料，配方参数和突变对非格司亭高阶结构的影响
2. Effects of Excipients on the Structure and Dynamics of Filgrastim Monitored by Thermal Unfolding Studies by CD and NMR Spectroscopy [J] . Houman Ghasriani, Grant E. Frahm, Michael J. W. Johnston, ACS Omega . 2020,第49期

机译：赋形剂对CD和NMR光谱热展位研究监测丝绒毛的结构和动力学的影响
3. Exploring ~(11)B and ~(15)N NMR parameters of C_(70-2x)(BN)_x fullerenes (x = 3-25) in connection with local structures and curvature effects: a DFT study [J] . Maryam Anafcheh, Reza Ghafouri Monatshefte fur Chemie . 2014,第3期

机译：探索C_（70-2x）（BN）_x富勒烯（x = 3-25）与局部结构和曲率效应相关的〜（11）B和〜（15）N NMR参数：DFT研究
4. Thermal Environmental Effects on Modal Parameters and Health Monitoring of Bridge Structures [C] . Mahendra P. Singh, Harsh Nandan, Surot Thangjitham IABSE symposium Bangkok 2009 : Sustainable infrastructure : Environment friendly, safe and resource efficient : Report . 2009

机译：热环境对模态参数的影响及桥梁结构健康监测
5. The effects of excipients on the structure and dynamics of insulin and the Lys(B28)Pro(B29) mutant: An NMR study. [D] . Hardaway, Lori Ann. 1994

机译：赋形剂对胰岛素和Lys（B28）Pro（B29）突变体的结构和动力学的影响：NMR研究。
6. Effects of Excipients on the Structure and Dynamicsof Filgrastim Monitored by Thermal Unfolding Studies by CD and NMRSpectroscopy [O] . Houman Ghasriani, Grant E. Frahm, Michael J. W. Johnston, 2020

机译：赋形剂对结构和动力学的影响由CD和NMR的热展开研究监测的菲格拉特光谱学
7. The effects of excipients on the structure and dynamics of insulin and the Lys(B28)Pro(B29) mutant: An NMR study. [O] . Hardaway Lori Ann. 1994

机译：赋形剂对胰岛素和Lys（B28）Pro（B29）突变体的结构和动力学的影响：NMR研究。

Monitoring Effects of Excipients, Formulation Parameters and Mutations on the High Order Structure of Filgrastim by NMR

摘要

著录项

相似文献

相关主题

期刊订阅