Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling of the Dopamine D<sub>2</sub> Receptor Occupancy of Olanzapine in Rats

Martin Johnson; Magdalena Kozielska; Venkatesh Pilla Reddy; An Vermeulen; Cheryl Li; Sarah Grimwood; Rik de Greef; Geny M. M. Groothuis; Meindert Danhof; Johannes H. Proost

首页> 外文期刊>Pharmaceutical Research >Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling of the Dopamine D₂ Receptor Occupancy of Olanzapine in Rats

【24h】

Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling of the Dopamine D₂ Receptor Occupancy of Olanzapine in Rats

机译：大鼠奥氮平多巴胺D _{2 受体占有率的基于机制的药代动力学-药效学模拟}

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Purpose A mechanism-based PK-PD model was developed to predict the time course of dopamine D₂ receptor occupancy (D₂RO) in rat striatum following administration of olanzapine, an atypical antipsychotic drug.

机译：目的建立基于机制的PK-PD模型，以预测大鼠服用奥氮平（Olanzapine）后纹状体中多巴胺D _{2 受体占据（D _{2 RO）的时间过程非典型抗精神病药。}}

著录项

来源
《Pharmaceutical Research》 |2011年第10期|p.2490-2504|共15页
作者
Martin Johnson; Magdalena Kozielska; Venkatesh Pilla Reddy; An Vermeulen; Cheryl Li; Sarah Grimwood; Rik de Greef; Geny M. M. Groothuis; Meindert Danhof; Johannes H. Proost;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. Mechanism-based pharmacokinetic-pharmacodynamic modeling of the dopamine D2 receptor occupancy of olanzapine in rats. [J] . Johnson M, Kozielska M, Pilla Reddy V, Pharmaceutical research . 2011,第10期

机译：奥氮平在大鼠中多巴胺D2受体占有率的基于机理的药代动力学-药效学建模。
2. Predicting the dopamine D-2 receptor occupancy of ropinirole in rats using positron emission tomography and pharmacokinetic-pharmacodynamic modeling [J] . Huang Chenrong, Wang Ziteng, Liu Linsheng, Xenobiotica: the fate of foreign compounds in biological systems . 2019,第1a6期

机译：使用正电子发射断层扫描和药代动力学 - 药效模型预测大鼠大鼠罗比里奥洛唑的多巴胺D-2受体占用
3. Dopamine D2 receptor occupancy study of ropinirole in rats using pet and its pharmacokinetic - pharmacodynamic modeling [J] . Huang Chenrong, Miao Liyan, Wang Ziteng Drug Metabolism Reviews . 2016,第1a4期

机译：宠物对大鼠吡吡胺多巴胺D2受体的占用及其药代动力学研究。
4. Linkage of Diisopropylfluorophosphate Exposure and Effects in Rats Using a Physiologically Based Pharmacokinetic and Pharmacodynamic Model [C] . K.Y. Seng, S. Teo, K. Chen International Conference on Biomedical Engineering . 2008

机译：二异丙基氟磷酸磷酸盐暴露的联动及效应在生理基础的药代动力学和药学模型
5. Mechanism-based pharmacokinetic/pharmacodynamic PK/PD modeling of corticosteroids and antiretrovirals. [D] . Fang, Jing. 2012

机译：皮质类固醇和抗逆转录病毒药物的基于机理的药代动力学/药效动力学PK / PD建模。
6. Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling of the Dopamine D2 Receptor Occupancy of Olanzapine in Rats [O] . Martin Johnson, Magdalena Kozielska, Venkatesh Pilla Reddy, -1

机译：大鼠奥氮平多巴胺D2受体占有率的基于机制的药代动力学-药效学建模
7. Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling of the Dopamine D-2 Receptor Occupancy of Olanzapine in Rats [O] . Johnson, Martin, Kozielska, Magdalena, Reddy, Venkatesh Pilla, 2011

机译：大鼠奥氮平多巴胺D-2受体占有率的基于机制的药代动力学-药效学建模

Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling of the Dopamine D2 Receptor Occupancy of Olanzapine in Rats

摘要

著录项

相似文献

相关主题

期刊订阅

Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling of the Dopamine D₂ Receptor Occupancy of Olanzapine in Rats