siRNA-Mediated Down-Regulation of P-glycoprotein in a Xenograft Tumor Model in NOD-SCID Mice

Meysam Abbasi; Hamidreza Montazeri Aliabadi; Elaine H. Moase; Afsaneh Lavasanifar; Kamaljit Kaur; Raymond Lai; Charles Doillon; Hasan Uludağ

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siRNA-Mediated Down-Regulation of P-glycoprotein in a Xenograft Tumor Model in NOD-SCID Mice

机译：siRNA介导的NOD-SCID小鼠异种移植肿瘤模型中P-糖蛋白的下调

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Purpose The efficacy of chemotherapy is decreased due to over-expression of the drug transporter P-glycoprotein (P-gp). This study was conducted to determine the feasibility of down-regulating tumor P-gp levels with non-viral siRNA delivery in order to sensitize the tumors to drug therapy.

机译：目的由于药物转运蛋白P-糖蛋白（P-gp）的过表达，化疗的功效会降低。进行这项研究以确定用非病毒siRNA递送下调肿瘤P-gp水平的可行性，以使肿瘤对药物治疗敏感。

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《Pharmaceutical Research》 |2011年第10期|p.2516-2529|共14页
作者
Meysam Abbasi; Hamidreza Montazeri Aliabadi; Elaine H. Moase; Afsaneh Lavasanifar; Kamaljit Kaur; Raymond Lai; Charles Doillon; Hasan Uludağ;
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1. siRNA-mediated down-regulation of P-glycoprotein in a Xenograft tumor model in NOD-SCID mice. [J] . Abbasi M, Aliabadi HM, Moase EH, Pharmaceutical research . 2011,第10期

机译：siRNA介导的NOD-SCID小鼠异种移植肿瘤模型中P-糖蛋白的下调。
2. Gene therapy in a mouse tumor model of breastcancer by siRNA-mediated down-regulation of STAT3 [J] . Dr. Qingwei, Zhou Gene Therapy and Molecular Biology . 2012,第9期

机译：siRNA介导的STAT3下调在乳腺癌小鼠模型中的基因治疗
3. Down-regulation of MDR1 by Ad-DKK3 via Akt/NF kappa B pathways augments the anti-tumor effect of temozolomide in glioblastoma cells and a murine xenograft model [J] . Fujihara Toshitaka, Mizobuchi Yoshifumi, Nakajima Kohei, Journal of neuro-oncology. . 2018,第2期

机译：通过AKT / NF Kappa B途径通过AD-DKK3降低MDR1的调节增强了锭剂在胶质母细胞瘤细胞和鼠异种移植模型中的抗肿瘤作用
4. Gender-related differential induction of peritoneal macrophage alternative in xenograft mice tumor models between male and female [C] . Wu Yuanyuan, Yang Weiwei, Shen Pingping International symposium on pharmacogenomics and the regulation of drug metabolism enzymes and genes. . 2010

机译：雌雄异种移植小鼠肿瘤模型中腹膜巨噬细胞替代物的性别相关差异诱导
5. Targeted siRNA-mediated down-regulation of the expression of amyloid precursor and tau proteins implicated in Alzheimer's disease in neuroblastoma cell lines. [D] . Patel, Krishna. 2016

机译：靶向siRNA介导的神经母细胞瘤细胞系中与阿尔茨海默氏病有关的淀粉样蛋白前体和tau蛋白表达的下调。
6. Metformin synergistically suppress tumor growth with doxorubicin and reverse drug resistance by inhibiting the expression and function of P-glycoprotein in MCF7/ADR cells and xenograft models [O] . Ying Li, Meng Wang, Pei Zhi, 2018

机译：二甲双胍通过抑制MCF7 / ADR细胞和异种移植模型中P-糖蛋白的表达和功能协同阿霉素协同抑制肿瘤生长并逆转耐药性
7. Performance of Pyridylthiourea-Polyethylenimine Polyplex for siRNA-Mediated Liver Cancer Therapy in Cell Monolayer, Spheroid, and Tumor Xenograft Models [O] . Jean Baptiste Gossart, Etienne Pascal, Florent Meyer, 2017

机译：吡啶罗西脲 - 聚乙烯亚氨酸对细胞单层，球状和肿瘤异种移植模型进行siRNA介导的肝癌治疗的性能
8. Harnessing Autopsied DIPG Tumor Tissues for Orthotopic Xenograft Model Development in the Brain Stems of SCID Mice. [R] . Li, X. 2012

机译：利用尸检DIpG肿瘤组织进行sCID小鼠脑干原位异种移植模型的开发。

siRNA-Mediated Down-Regulation of P-glycoprotein in a Xenograft Tumor Model in NOD-SCID Mice

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