Acidic Microclimate pH Distribution in PLGA Microspheres Monitored by Confocal Laser Scanning Microscopy

Amy G. Ding; Steven P. Schwendeman

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Acidic Microclimate pH Distribution in PLGA Microspheres Monitored by Confocal Laser Scanning Microscopy

机译：共聚焦激光扫描显微镜监测PLGA微球中的酸性微气候pH分布

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摘要

The acidic microclimate pH (μpH) distribution inside poly(lactic-co-glycolic acid) (PLGA) microspheres was monitored quantitatively as a function of several formulation variables.

机译：根据几个配方变量，对聚乳酸-乙醇酸（PLGA）微球内部的酸性微气候pH（μpH）分布进行了定量监测。

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来源
《Pharmaceutical Research》 |2008年第9期|2041-2052|共12页
作者
Amy G. Ding; Steven P. Schwendeman;
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作者单位

Department of Pharmaceutical Sciences University of Michigan Ann Arbor Michigan 48109-1065 USA;

Department of Pharmaceutical Sciences University of Michigan Ann Arbor Michigan 48109-1065 USA;

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原文格式 PDF
正文语种 eng
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关键词
confocal laser scanning microscopy; microclimate pH; microspheres; pH distribution; Poly(ethylene glycol); Poly(lactic-co-glycolic acid);

机译：共聚焦激光扫描显微镜;微气候pH;微球;pH分布;聚乙二醇;聚乳酸-乙醇酸共聚物;

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专利

1. Acidic microclimate pH distribution in PLGA microspheres monitored by confocal laser scanning microscopy. [J] . Ding AG, Schwendeman SP Pharmaceutical research . 2008,第9期

机译：共聚焦激光扫描显微镜监测PLGA微球中的酸性微气候pH分布。
2. Mapping microclimate pH distribution inside protein-encapsulated PLGA microspheres using confocal laser scanning microscopy [J] . LiuY., SchwendemanS.P. Molecular pharmaceutics . 2012,第5期

机译：使用共聚焦激光扫描显微镜绘制蛋白质封装的PLGA微球内部的微气候pH分布图
3. Ligand Distributions in Agarose Particles as Determined by Confocal Raman Spectroscopy and Confocal Scanning Laser Microscopy [J] . Applied Spectroscopy: Society for Applied Spectroscopy . 2003,第3期

机译：共焦拉曼光谱和共聚焦扫描激光显微镜确定的琼脂糖颗粒中的配体分布
4. Acidic Microclimate pH Mapping in PLGA Microspheres by Confocal Laser ScanningMicroscopy [C] . Amy G. Ding, Steven P. Schwendeman Annual meeting exposition of the Controlled Release Society . 2005

机译：共聚焦激光扫描显微镜在PLGA微球中酸性微气候pH定位
5. Cumulus cell, ooplasmic, and nuclear morphology of periovulatory equine oocytes and ova by confocal laser scanning microscopy. [D] . Miragaya, Marcelo Horacio. 1999

机译：通过共聚焦激光扫描显微镜观察，排卵期马卵母细胞和卵的卵丘细胞，卵质和核形态。
6. Acidic Microclimate pH Distribution in PLGA Microspheres Monitored by Confocal Laser Scanning Microscopy [O] . Amy G. Ding, Steven P. Schwendeman -1

机译：共聚焦激光扫描显微镜监测PLGA微球中的酸性微气候pH分布
7. Mapping Microclimate pH Distribution inside Protein-Encapsulated PLGA Microspheres Using Confocal Laser Scanning Microscopy [O] . Yajun Liu, Steven P. Schwendeman 2012

机译：使用共聚焦激光扫描显微镜映射蛋白质包封的PLGA微球内的微气候pH分布
8. Effects of Phorbol Esters on Endothelial Cell Microfilaments: Laser Scanning Confocal Microscopy and Quantitative Morphometry of Dose Dependent Changes. [R] . Nielsen, T. B., Wood, D. K. 1989

机译：佛波酯对内皮细胞微丝的影响：激光扫描共聚焦显微镜和剂量依赖性变化的定量形态测定。

Acidic Microclimate pH Distribution in PLGA Microspheres Monitored by Confocal Laser Scanning Microscopy

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